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Characterization of the interaction of daptomycin with bacterial liposomal analogues
Descriptive
TitleInfo
Title
Characterization of the interaction of daptomycin with bacterial liposomal analogues
Name
(type = personal)
NamePart
(type = family)
Varghese
NamePart
(type = given)
Nevin
DisplayForm
Nevin Varghese
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Sofou
NamePart
(type = given)
Stavroula
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Stavroula Sofou
Affiliation
Advisory Committee
Role
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(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Pierce
NamePart
(type = given)
Mark
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Mark Pierce
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Langrana
NamePart
(type = given)
Noshir
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Noshir Langrana
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - New Brunswick
Role
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school
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Text
Genre
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theses
OriginInfo
DateCreated
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2016
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(type = degree)
2016-10
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2016
Place
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(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Efforts to curb the prevalence of antibiotic resistant bacteria are unable to keep up with the aggressive adaptation of these bacterial species to existing antibiotics. Therefore, examining the interaction of existing antibiotics with bacteria may reveal previously unknown bacterial susceptibilities. Daptomycin is a typical second-line treatment for antibiotic-resistant gram positive bacterial strains, like methicillin-resistant Staphylococcus aureus (MRSA). Its proposed mechanism of action is to bind to the negatively charged phosphatidyglycerol (PG) head groups of the bacterial cytoplasmic membrane via a calcium ion dependent process. However, the specific mechanisms by which daptomycin exerts its bacteriocidality are currently unknown. It has been hypothesized that bacterial membrane rigidity may have an effect on susceptibility to daptomycin. Additionally, there is evidence to suggest that the charge of the bacterial membrane charge affects daptomycin's mechanism of action. Our study aims to systematically analyze the interaction of daptomycin with liposomal bacterial analogues by varying the rigidity and the zeta potential of the liposomes. Our results show possible mechanisms for targeting daptomycin resistance in gram positive bacteria.
Subject
(authority = RUETD)
Topic
Biomedical Engineering
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
Identifier
ETD_7540
PhysicalDescription
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electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (viii, 31 p. : ill.)
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Subject
(authority = ETD-LCSH)
Topic
Liposomes
Subject
(authority = ETD-LCSH)
Topic
Drug resistance in microorganisms
Note
(type = statement of responsibility)
by Nevin Varghese
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3765HPD
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Varghese
GivenName
Nevin
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(qualifier = exact);
(point = start)
2016-09-08 13:43:53
AssociatedEntity
Name
Nevin Varghese
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
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(qualifier = exact);
(point = start)
2016-10-31
DateTime
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(qualifier = exact);
(point = end)
2018-10-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 31st, 2018.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ETD
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windows xp
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1.5
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2016-09-06T07:25:59
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2016-09-06T07:25:59
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