RUcore: Rutgers University Community Repository
Regulation of organic anion transporters
Descriptive
TitleInfo
Title
Regulation of organic anion transporters
Name
(type = personal)
NamePart
(type = family)
Xu
NamePart
(type = given)
Da
NamePart
(type = date)
1985-
DisplayForm
Da Xu
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
You
NamePart
(type = given)
Guofeng
DisplayForm
Guofeng You
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Hatefi
NamePart
(type = given)
Arash
DisplayForm
Arash Hatefi
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Kagan
NamePart
(type = given)
Leonid
DisplayForm
Leonid Kagan
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Guo
NamePart
(type = given)
Grace
DisplayForm
Grace Guo
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2016
DateOther
(qualifier = exact);
(type = degree)
2016-10
CopyrightDate
(encoding = w3cdtf);
(qualifier = exact)
2016
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Organic anion transporters (OATs) are a group of transporters that interact with organic anionic molecules or zwitterions in our body. OATs mainly exist in the kidney and mediate the disposition of a wide range of endogenous physiological substances, exogenous clinical drugs and toxins. Thus, to understand the regulation of OATs has profound physiological and clinical significance. Like other proteins, OATs can be regulated at different levels from gene to protein, including at transcriptional, post-transcriptional, translational, and post-translational stages. This dissertation mainly focuses on the regulation of OATsat post-translational levels, specifically the role of ubiquitination in regulating OATs. In the first part, an overview of OATs and their regulation will be introduced. Several mechanisms underlying the post-translational regulation of OATs uncovered previouslyby our laboratory will be elaborated, including the regulation of OATs by ubiquitination. From the second to the fifth part, I will introduce our detailed investigation underlying protein kinase-regulated OAT ubiquitination and function; specific emphasis will be placed on identification of ubiquitin enzymes. In the last part, I will summarize about my research and propose the future direction for the study.
Subject
(authority = RUETD)
Topic
Pharmaceutical Science
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_7606
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xv, 146 p. : ill.)
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Subject
(authority = ETD-LCSH)
Topic
Drug delivery systems
Subject
(authority = ETD-LCSH)
Topic
Anions
Note
(type = statement of responsibility)
by Da Xu
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3M90C1S
Genre
(authority = ExL-Esploro)
ETD doctoral
Back to the top
Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Xu
GivenName
Da
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2016-09-21 16:46:04
AssociatedEntity
Name
Da Xu
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
Back to the top
Technical
RULTechMD
(ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
CreatingApplication
Version
1.3
ApplicationName
http://www.convertapi.com
DateCreated
(point = start);
(encoding = w3cdtf);
(qualifier = exact)
2016-09-27T08:47:45
DateCreated
(point = start);
(encoding = w3cdtf);
(qualifier = exact)
2016-09-27T08:47:44
Back to the top
Statistical Profile