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Linoleic acid causes greater weight gain than saturated fat without hypothalamic inflammation in the male mouse

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TypeOfResource
Text
TitleInfo
Title
Linoleic acid causes greater weight gain than saturated fat without hypothalamic inflammation in the male mouse
Identifier (type = pmcid)
PMC5235953
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Animal Sciences
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
School of Environmental and Biological Sciences (SEBS)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
Note (type = peerReview)
Peer reviewed
OriginInfo
DateIssued (encoding = w3cdtf); (keyDate = yes)
2017
Abstract (type = Abstract)
A significant change in the Western diet, concurrent with the obesity epidemic, was a substitution of saturated fatty acids with polyunsaturated, specifically linoleic acid (LA). Despite increasing investigation on type as well as amount of fat, it is unclear which fatty acids are most obesogenic. The objective of this study was to determine the obesogenic potency of LA vs. saturated fatty acids and the involvement of hypothalamic inflammation. Forty-eight mice were divided into four groups: low-fat or three high-fat diets (HFDs, 45% kcals from fat) with LA comprising 1%, 15% and 22.5% of kilocalories, the balance being saturated fatty acids. Over 12 weeks, bodyweight, body composition, food intake, calorimetry, and glycemia assays were performed. Arcuate nucleus and blood were collected for mRNA and protein analysis. All HFD-fed mice were heavier and less glucose tolerant than control. The diet with 22.5% LA caused greater bodyweight gain, decreased activity, and insulin resistance compared to control and 1% LA. All HFDs elevated leptin and decreased ghrelin in plasma. Neuropeptides gene expression was higher in 22.5% HFD. The inflammatory gene Ikk was suppressed in 1% and 22.5% LA. No consistent pattern of inflammatory gene expression was observed, with suppression and augmentation of genes by one or all of the HFDs relative to control. These data indicate that, in male mice, LA induces obesity and insulin resistance and reduces activity more than saturated fat, supporting the hypothesis that increased LA intake may be a contributor to the obesity epidemic.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
38 p.
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2017
AssociatedObject
Name
Journal of Nutritional Biochemistry
Type
Journal
Relationship
Has part
Detail
122-131
Identifier (type = volume and issue)
40
Reference (type = url)
http://dx.doi.org/10.1016/j.jnutbio.2016.10.016
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedEntity
Role
Originator
Name
Troy A Roepke
AssociatedObject
Type
Grant number
Name
R00DK083457
Subject (authority = local)
Topic
Obesity
Subject (authority = local)
Topic
HFD
Subject (authority = local)
Topic
Hypothalamic inflammation
Subject (authority = local)
Topic
Saturated fat
Subject (authority = local)
Topic
PUFA
Subject (authority = local)
Topic
Linoleic acid
Name (type = personal)
NamePart (type = family)
Mamounis
NamePart (type = given)
Kyle
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Yasrebi
NamePart (type = given)
Ali
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0001-5426-2266)
NamePart (type = family)
Roepke
NamePart (type = given)
Troy A.
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
RelatedItem (type = host)
TitleInfo
Title
Roepke, Troy A.
Identifier (type = local)
rucore30176800001
RelatedItem (type = host)
TitleInfo
Title
Mamounis, Kyle J.
Identifier (type = local)
rucore30196300001
RelatedItem (type = host)
TitleInfo
Title
Yasrebi, Ali
Identifier (type = local)
rucore30190700001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3TF00QF
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Rights

RightsDeclaration (AUTHORITY = FS); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsEvent
Type
Embargo
DateTime (encoding = w3cdtf); (point = end); (qualifier = exact); (keyDate = no)
2018-01-31
DateTime (encoding = w3cdtf); (point = start); (qualifier = exact); (keyDate = no)
2017-02-01
Detail
Access to this PDF has been restricted at the publisher's request. It will be publicly available after January 31, 2018.
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
Document
CreatingApplication
Version
1.7
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2016-10-27T14:40:55
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2017-02-13T18:36:43
ApplicationName
Aspose.Pdf for Java 11.5.0
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