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Activation of Estrogen Response Element-independent ERα signaling protects female mice from diet-induced obesity

Descriptive

TypeOfResource
Text
TitleInfo
Title
Activation of Estrogen Response Element-independent ERα signaling protects female mice from diet-induced obesity
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Animal Sciences
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
School of Environmental and Biological Sciences (SEBS)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
Note (type = peerReview)
Peer reviewed
OriginInfo
DateIssued (encoding = w3cdtf); (keyDate = yes)
2017
Abstract (type = Abstract)
17β-estradiol (E2) regulates central and peripheral mechanisms that control energy and glucose homeostasis predominantly through estrogen receptor α (ERα) acting via receptor binding to estrogen response elements (ERE). ERα signaling is also involved in mediating the effects of E2 on diet-induced obesity (DIO), although the roles of ERE-dependent and -independent ERα signaling in ameliorating the effects of DIO remain largely unknown. We hypothesize that ERE-dependent ERα signaling is necessary to ameliorate the effects of DIO. We addressed this question using ERαKO (KO) and ERαKIKO (KIKO) female mice; the latter expressing an ERα that lacks a functional ERE binding domain. Females were ovariectomized, fed low-fat (LFD) or high-fat (HFD) diet, and orally dosed with vehicle or estradiol benzoate (EB, 300 μg/kg). After 9 weeks, body composition, glucose and insulin tolerance, peptide hormone and inflammatory cytokine levels, and hypothalamic arcuate nucleus and liver gene expression were assessed. EB reduced body weight and body fat in WT, regardless of diet, and in HFD-fed KIKO, in part by reducing energy intake and feeding efficiency. EB reduced fasting glucose levels in KIKO mice fed both diets but augmented glucose tolerance only in HFD-fed KIKO. Plasma insulin and IL-6 were elevated in KIKO and KO compared to WT on a LFD. Expression of arcuate neuropeptide and receptor genes and liver fatty acid biosynthesis genes was altered by HFD and by EB through ERE-dependent and -independent mechanisms. Therefore, ERE-independent signaling mechanisms in both the brain and peripheral organs mediate, in part, the effects of E2 during DIO.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
38 p.
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2017
AssociatedObject
Name
Endocrinology
Type
Journal
Relationship
Has part
Detail
319-334
Identifier (type = volume and issue)
158(2)
Reference (type = url)
http://dx.doi.org/10.1210/en.2016-1535
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedEntity
Role
Originator
Name
Troy A Roepke
AssociatedObject
Type
Grant number
Name
R00DK083457
Subject (authority = local)
Topic
Cytokine
Subject (authority = local)
Topic
Obesity
Subject (authority = local)
Topic
Signal transduction
Subject (authority = local)
Topic
Gene expression
Subject (authority = local)
Topic
Estrogen
Subject (authority = local)
Topic
Glucose
Subject (authority = local)
Topic
Diet
Subject (authority = local)
Topic
Genes
Subject (authority = local)
Topic
Response elements
Subject (authority = local)
Topic
Insulin
Subject (authority = local)
Topic
Liver
Subject (authority = local)
Topic
Mice
Name (type = personal)
NamePart (type = family)
Yasrebi
NamePart (type = given)
Ali
Role
RoleTerm (authority = marcrt); (type = text)
author
Affiliation
Animal Sciences, Rutgers University
Name (type = personal)
NamePart (type = family)
Rivera
NamePart (type = given)
Janelle
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Krumm
NamePart (type = given)
Elizabeth A.
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Yang
NamePart (type = given)
Jennifer A.
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0001-5426-2266)
NamePart (type = family)
Roepke
NamePart (type = given)
Troy A.
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
RelatedItem (type = host)
TitleInfo
Title
Roepke, Troy A.
Identifier (type = local)
rucore30176800001
RelatedItem (type = host)
TitleInfo
Title
Yasrebi, Ali
Identifier (type = local)
rucore30190700001
RelatedItem (type = host)
TitleInfo
Title
Krumm, Elizabeth A.
Identifier (type = local)
rucore30223500001
RelatedItem (type = host)
TitleInfo
Title
Yang, Jennifer A.
Identifier (type = local)
rucore30190600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3PN980K
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RightsDeclaration (AUTHORITY = FS); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsEvent
Type
Permission research
DateTime (encoding = w3cdtf)
2017-02-20
Detail
No embargo required for institutional repository posting. Journal policy at https://academic.oup.com/endo/pages/Author_Guidelines#repositories
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Technical

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Document
CreatingApplication
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1.6
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2016-11-22T13:18:12
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2017-02-13T18:43:10
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iTextSharp™ 5.5.9 ©2000-2016 iText Group NV (AGPL-version)
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