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Neuropeptide VGF Promotes Maturation of Hippocampal Dendrites That Is Reduced by Single Nucleotide Polymorphisms

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TypeOfResource
Text
TitleInfo
Title
Neuropeptide VGF Promotes Maturation of Hippocampal Dendrites That Is Reduced by Single Nucleotide Polymorphisms
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Neuroscience and Cell Biology
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
Robert Wood Johnson Medical School (RWJMS)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Version of Record (VoR)
Note (type = peerReview)
Peer reviewed
OriginInfo
DateIssued (encoding = w3cdtf); (keyDate = yes)
2017
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
18 p.
Subject (authority = local)
Topic
Neuropeptide
Subject (authority = local)
Topic
Dendrite
Subject (authority = local)
Topic
Single nucleotide polymorphism
Subject (authority = local)
Topic
Spine
Subject (authority = local)
Topic
Synapse
Subject (authority = local)
Topic
Hippocampus
Abstract (type = abstract)
The neuropeptide VGF (non-acronymic) is induced by brain-derived neurotrophic factor and promotes hippocampal neurogenesis, as well as synaptic activity. However, morphological changes induced by VGF have not been elucidated. Developing hippocampal neurons were exposed to VGF through bath application or virus-mediated expression in vitro. VGF-derived peptide, TLQP-62, enhanced dendritic branching, and outgrowth. Furthermore, VGF increased dendritic spine density and the proportion of immature spines. Spine formation was associated with increased synaptic protein expression and co-localization of pre- and postsynaptic markers. Three non-synonymous single nucleotide polymorphisms (SNPs) were selected in human VGF gene. Transfection of N2a cells with plasmids containing these SNPs revealed no relative change in protein expression levels and normal protein size, except for a truncated protein from the premature stop codon, E525X. All three SNPs resulted in a lower proportion of N2a cells bearing neurites relative to wild-type VGF. Furthermore, all three mutations reduced the total length of dendrites in developing hippocampal neurons. Taken together, our results suggest VGF enhances dendritic maturation and that these effects can be altered by common mutations in the VGF gene. The findings may have implications for people suffering from psychiatric disease or other conditions who may have altered VGF levels.
Name (type = personal)
NamePart (type = family)
Behnke
NamePart (type = given)
Joseph
Affiliation
Neuroscience and Cell Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Cheedalla
NamePart (type = given)
Aneesha
Affiliation
Neuroscience and Cell Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Bhatt
NamePart (type = given)
Vatsal
Affiliation
Neuroscience and Cell Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Bhat
NamePart (type = given)
Maysa
Affiliation
Neuroscience and Cell Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Teng
NamePart (type = given)
Shavoonne
Affiliation
Neuroscience and Cell Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Palmieri
NamePart (type = given)
Alicia
Affiliation
Neuroscience and Cell Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Windon
NamePart (type = given)
Charles Christian
Affiliation
Neuroscience and Cell Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Thakker-Varia
NamePart (type = given)
Smita
Affiliation
Neuroscience and Cell Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Alder
NamePart (type = given)
Janet
Affiliation
Neuroscience and Cell Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2017
AssociatedObject
Type
Journal
Relationship
Has part
Name
International Journal of Molecular Sciences
Identifier (type = volume and issue)
18(3)
Reference (type = url)
http://dx.doi.org/10.3390/ijms18030612
Detail
612
RelatedItem (type = host)
TitleInfo
Title
Alder, Janet
Identifier (type = local)
rucore30160300001
RelatedItem (type = host)
TitleInfo
Title
Bhat, Maysa
Identifier (type = local)
rucore30227100001
RelatedItem (type = host)
TitleInfo
Title
Teng, Shavonne
Identifier (type = local)
rucore30227300001
RelatedItem (type = host)
TitleInfo
Title
Windon, Charles Christian
Identifier (type = local)
rucore30227400001
RelatedItem (type = host)
TitleInfo
Title
Thakker-Varia, Smita
Identifier (type = local)
rucore30188900001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T31N83JD
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Multiple author license v. 1
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Permission or license
AssociatedObject
Type
License
Name
Creative Commons Attribution (CC BY) license
Reference (type = digital)
https://creativecommons.org/licenses/by/4.0/
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2017-03-13T14:42:04
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