Home
Resource
Advanced molecular design to replace poly(α-hydroxy acid)s in biomedical applications
PDF
PDF format is widely accepted and good for printing.
Plug-in required
PDF-1(10.53 MB)
Citation & Export
View Usage Statistics
Staff View

Citation & Export
Hide

Simple citation

Dube, Koustubh Shishir. Advanced molecular design to replace poly(α-hydroxy acid)s in biomedical applications. Retrieved from https://doi.org/doi:10.7282/T37S7R6N

Export

Click here for information about Citation Management Tools at Rutgers.

Statistics
Hide

Description

TitleAdvanced molecular design to replace poly(α-hydroxy acid)s in biomedical applications
NameDube, Koustubh Shishir (author); Kohn, Joachim (chair); Rutgers University; Graduate School - New Brunswick
Date Created2017
Other Date2017-01 (degree)
SubjectChemistry and Chemical Biology, Biomedical materials, Polymers
Extent1 online resource (xxiii, 152 p. : ill.)
DescriptionAdvances in biomaterials can be brought about by the development of novel polymers that are designed to satisfy multiple criteria. Some of these criteria are biodegradability, biocompatibility, processability to fabricate into different architectures, and appropriate mechanical properties. Modifying currently existent polymeric biomaterials only gives limited control over desired properties; these properties can be easily tuned when new polymers are designed. One important aspect for the advancement of biomaterials is the ability to functionalize them by attaching biomolecules to create or enhance the regenerative response in the body. While such reactivity is actively being explored in soft polymeric biomaterials such as hydrogels, bioconjugation of biomolecules to stiff polymers has not been investigated. In this dissertation, the synthesis and properties of novel polymers synthesized from naturally occurring molecules such as tyrosol and 2-(4-hydroxyphenyl)acetic acid are reported. The polymers were incorporated with pendant chemical groups that can undergo ‘click’ reactions under physiological conditions. The reactivity of the polymers towards thiol containing small molecule, thiol containing proteins, and proteins and polysaccharides modified with azide group is reported. It was discovered that it is possible to fabricate the designed polymers into computer-aided architectures by fused deposition modeling. Additionally, in this thesis, the structure-property relationship of polycarbonates derived from diesters of 2-(4-hydroxyphenyl)acetic acid and 2-(4-hydroxyphenyl)propionic acid with alkane diols are explored in Chapter 5. The striking difference in thermal and mechanical properties by a small change in the chemical composition of the monomer is noted. Finally, independent research work done on tyrosine-derived polycarbonates is presented in Appendix 1 and 2.
NotePh.D.
NoteIncludes bibliographical references
Noteby Koustubh Shishir Dube
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/T37S7R6N
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
Version 8.5.5
Rutgers University Libraries - Copyright ©2024