DescriptionThe kinematic analysis of joint motion has proven to significantly improve orthopedic surgeries by enhancing surgery assessment, prosthesis design, and pathology diagnosis. This analysis is usually performed by a three to two dimensional (3D/2D) registration of the 3D bone model to a 2D radiographic video from C-arm fluoroscopy imaging machines. However, the practicality of such analysis is undermined due to lengthy and user-dependent 3D/2D image registration algorithms and the high cost of C-arm fluoroscopy imaging machines. Mini C-arm fluoroscopic machines are a more affordable alternative, but the low quality of their images has hindered their use in this application. In this thesis, we propose a novel 3D/2D image registration algorithm for the kinematic analysis of joint bones using mini C-arm fluoroscopy machines with significantly improved speed, despite their low quality images. This method performs a fast registration through a novel algorithm for quick and high-quality generation of digitally reconstructed radiographs (DRR), which is the bottleneck in such processes. Moreover, the dependency of the results on the user has been reduced as a new feature-based registration algorithm replaced the previously manual initialization phase of the process. This algorithm is able to reach the true registration from within 90 degrees of it, which is a substantial improvement over the existing methods. In addition, our algorithm performs the registration in significantly reduced time due to a smaller number of generated DRRs.