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A phytochemical exploration of Griffonia simplicifolia seeds and leaves

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TitleInfo
Title
A phytochemical exploration of Griffonia simplicifolia seeds and leaves
Name (type = personal)
NamePart (type = family)
Giurleo
NamePart (type = given)
Daniel
NamePart (type = date)
1986-
DisplayForm
Daniel Giurleo
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Simon
NamePart (type = given)
James E
DisplayForm
James E Simon
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2017
DateOther (qualifier = exact); (type = degree)
2017-01
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2017
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Griffonia simplicifolia is a legume indigenous to western region of Sub-Saharan Africa. While the seeds of this plant are known for being the most abundant natural source of 5-hydroxtryptophan (5-HTP), a widely consumed alternative treatment for conditions involving a serotonin imbalance, many phytochemical characteristics of this species remain unreported. In order to further characterize the phytochemical composition of Griffonia simplicifolia, the 5-HTP, nitrile glycoside, polyphenol, antioxidant, protein, flavonoid, mineral, fatty acids, and tocopherol content of several different populations of griffonia seeds and leaves collected from various regions of Ghana and Liberia were evaluated. For comparison, the 5-HTP content of 18 commercial products on the nutraceutical supplement market was quantified in order to verify the declared amount on their labels match their measured amount. Total polyphenol content of griffonia leaves was 21.16 ± 0.48 GAE/g and antioxidant capacities of leaves and seeds were 12.31 ± 0.45 TEAC/g and 216.50 ± 13.88 TEAC/g, respectively. Protein content of griffonia leaves was 6.89 ± 0.47 BSAE/gram and protein content of seeds was 33.58 ± 1.52 BSAE/gram. Average fatty acid, α-tocopherol, and γ-tocopherol content of seeds were 269.54 ± 2.77 mg/g, 22.62 ± 1.54 µg/g, and 86.58 ± 4.01 µg/g, respectively. Average flavonoid content of griffonia leaves was 9182.02 ± 140.90 µg/g. The average 5-HTP content from all the sampled seed populations was 120.84 ± 9.00 mg/g and total nitrile glycosides averaged 14.25 ± 1.65 mg/g. Griffonia seeds were found to be a source of manganese but not calcium, and a high source of iron, zinc, magnesium, copper, and phosphorus. Among the various populations, the most substantial differences in secondary metabolite accumulation was observed in polyphenol, antioxidant, and flavonoid content of leaves as well as nitrile glycoside and tocopherol content of seeds. Pasteurizing seeds with dry heat does not significantly affect the 5-HTP content and seeds with black colored endosperms contained lower amounts of 5-HTP and nitrile glycosides than seeds with yellow endosperms. The 5-HTP content of all 18 dietary supplements was within ± 15% of the amounts declared on their labels.
Subject (authority = RUETD)
Topic
Medicinal Chemistry
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_7873
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xxi, 210 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Subject (authority = ETD-LCSH)
Topic
Legumes--Physiology
Note (type = statement of responsibility)
by Daniel Giurleo
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3NC63NT
Genre (authority = ExL-Esploro)
ETD graduate
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RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Giurleo
GivenName
Daniel
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2017-01-13 15:16:57
AssociatedEntity
Name
Daniel Giurleo
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
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Type
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Name
Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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ETD
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windows xp
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2017-01-13T14:59:23
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2017-01-13T14:59:23
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