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Potential role of methylglyoxal in inducing Parkinson’s disease
Descriptive
TitleInfo
Title
Potential role of methylglyoxal in inducing Parkinson’s disease
Name
(type = personal)
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Liu
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Siyu
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Siyu Liu
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author
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HO
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CHI-TANG
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CHI-TANG HO
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Advisory Committee
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chair
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Hartman
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Thomas G.
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Thomas G. Hartman
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Advisory Committee
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internal member
Name
(type = personal)
NamePart
(type = family)
Wu
NamePart
(type = given)
Qingli
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Qingli Wu
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Advisory Committee
Role
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internal member
Name
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Rutgers University
Role
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(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - New Brunswick
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(authority = RULIB)
school
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Text
Genre
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theses
OriginInfo
DateCreated
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2017
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2017-01
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2017
Place
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xx
Language
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(type = code)
eng
Abstract
(type = abstract)
About one and a half million people are affected by Parkinson’s disease (PD) in the United States. It is a neurodegenerative disorder on dopaminergic neurons in the substantia nigra pars compacta, with primary effects on motion disorder. The causes for the Parkinsonism are generally divide into genetic factors like mutation and environmental factors like heavy metals as well as some endogenous or exogenous agents. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and other MPTP-like neurotoxins such as salsolinol are well known and considered to cause Parkinsonism due to their in vivo metabolic products’ specific toxicity for dopaminergic neurons. Recent studies showed that the diabetic patient is more likely to develop the Parkinson’s disease. It has been suspected that the methylglyoxal, one metabolic product of glycolysis, is associated with this phenomenon because the body concentration of methylglyoxal for diabetic patients will be three to six times higher than healthy people. The dopamine-derived tetrahydroisoquinoline (TIQ), 1-acetyl-6,7-dihydroxyl-1,2,3,4-tetrahydro- isoquinoline (ADTIQ), has been detected in frozen brain tissue of human with Parkinson’s disease. It can be produced by the reaction of dopamine and methylglyoxal in physiological condition and has been regarded a novel endogenous neurotoxins. In our study, in addition to ADTIQ, 6,7-dihydroxy-1,2,3,4-tetrahydro- isoquinoline or called norsalsolinol was also detected in the reaction system of dopamine and methylglyoxal by LC-MS/MS. And based on the Pictect-Spengler reaction, there are two regioselectivities for the products under neutral conditions. So there are two isomers for both ADTIQ and norsalsolinol. Additionally, according to the proposed reaction mechanism, the norsalsolinol was generated from ADTIQ by deacylation. On the other hand, with different ratios of dopamine and methylglyoxal, different levels of reaction under the physiological condition were also monitored by HPLC-UV. It revealed that when the ratio of dopamine and methylglyoxal is over 1:10, the reaction could almost be completed within 24 hours. In conclusion, we showed for the first time that the potential neurotoxin norsalsolinol could be generated through the reaction of dopamine and methylglyoxal. And also can be one reason why the norsalsolinol was detected in the frozen brain of humans.
Subject
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Topic
Food Science
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
Identifier
ETD_7794
PhysicalDescription
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electronic resource
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application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xi, 87 p. : ill.)
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Subject
(authority = ETD-LCSH)
Topic
Parkinson's disease
Note
(type = statement of responsibility)
by Siyu Liu
RelatedItem
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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NjNbRU
Identifier
(type = doi)
doi:10.7282/T3HH6NHS
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Liu
GivenName
Siyu
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(point = start)
2016-12-21 22:04:22
AssociatedEntity
Name
Siyu Liu
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
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Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
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2017-01-31
DateTime
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2018-01-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after January 31st, 2018.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ETD
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windows xp
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1.4
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2016-12-08T03:31:38
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2016-12-08T03:31:38
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