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Inflammation and post-stroke depression
Descriptive
TitleInfo
Title
Inflammation and post-stroke depression
Name
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NamePart
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Norton
NamePart
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Sara Ann
NamePart
(type = date)
1991-
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Sara Ann Norton
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(authority = RULIB)
author
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Kusnecov
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(type = given)
Alexander
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Alexander Kusnecov
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Advisory Committee
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(authority = RULIB)
chair
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(type = personal)
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(type = family)
Wagner
NamePart
(type = given)
George
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George Wagner
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Advisory Committee
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internal member
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(type = personal)
NamePart
(type = family)
Shors
NamePart
(type = given)
Tracey
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Tracey Shors
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
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NamePart
Rutgers University
Role
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(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - New Brunswick
Role
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school
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Text
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theses
OriginInfo
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2017
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2017-01
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2017
Place
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xx
Language
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eng
Abstract
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Acute ischemic stroke (AIS) has been associated with elevations in circulating inflammatory cytokines. In addition, a subset of AIS patients can develop clinically significant depression (post-stroke depression [PSD]), which can compromise recovery and increase recurrence of stroke. The cytokines, interleukin1β (IL1β), tumor necrosis factor α (TNFα), and interleukin6 (IL6) are known to have neuromodulatory effects, including the induction of behavioral changes similar to depressive symptomatology. Moreover, increased circulating levels of these cytokines – in particular, IL6 have been observed in depressed individuals. Therefore, it is possible that the development of PSD may similarly be associated with increased levels of inflammatory cytokines. In the current study, we recruited 25 AIS patients and assessed executive cognition, clinical depression, and circulating IL1β, TNFα and IL6. Each of these variables was measured at three time points following admission for AIS: (A) 12 days, (B) 57 days, and (C) 90 days. Depression was assessed throughout using the Hamilton Depression Scale and Beck Depression Inventory, as well as a structured diagnostic interview for depression (SCID) on Day 90. Cognitive functioning was measured using the RBANS. Additional repeated measures of functional and neurological status were obtained using the modified Rankin Scale (mRS) and the National Institute of Health Stroke Scale (NIHSS). Of those patients that completed all three time points (n=22), six showed detectable levels of plasma IL6 within seven days of AIS. A further three patients (13.6%) showed evidence for PSD at Day 90, but none of these had detectable IL6 at any time point. Contrary to expectations, no patients, at any time point, had detectable plasma levels of TNFα or IL1β. Based on evidence that IL6 may be neuroprotective in animal studies of stroke, the current findings, although based on a small cohort of patients, lend themselves to the novel hypothesis that failure to generate plasma IL6 elevations after AIS is associated with PSD and poor cognitive recovery.
Subject
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Topic
Psychology
Subject
(authority = ETD-LCSH)
Topic
Depression, Mental
Subject
(authority = ETD-LCSH)
Topic
Medical rehabilitation
Subject
(authority = ETD-LCSH)
Topic
Cerebrovascular disease
Subject
(authority = ETD-LCSH)
Topic
Inflammation
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Rutgers University Electronic Theses and Dissertations
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ETD_7804
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electronic resource
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application/pdf
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text/xml
Note
Supplementary File: NIH Stroke Scale
Extent
1 online resource (v, 39 p.)
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Sara Ann Norton
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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NjNbRU
Identifier
(type = doi)
doi:10.7282/T3XK8J00
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
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The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Norton
GivenName
Sara
MiddleName
Ann
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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2016-12-27 12:54:44
AssociatedEntity
Name
Sara Norton
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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