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Apply DEM to study wet binder addition and dry binder addition wet granulation in a high shear granulator
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Chen, Sheng-Wen. Apply DEM to study wet binder addition and dry binder addition wet granulation in a high shear granulator. Retrieved from https://doi.org/doi:10.7282/T3319ZQS

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TitleApply DEM to study wet binder addition and dry binder addition wet granulation in a high shear granulator
NameChen, Sheng-Wen (author); Ramachandran, Rohit (chair); Glasser, Benjamin (internal member); Singh, Ravendra (internal member); Rutgers University; Graduate School - New Brunswick
Date Created2017
Other Date2017-05 (degree)
SubjectChemical and Biochemical Engineering, Granular materials, Binders (Materials)
Extent1 online resource (vi, 41 p. : ill.)
DescriptionWet granulation is widely used in many industries especially in the pharmaceutical industry for its capability to improve flowability and handling of powder substances. A discrete element model (DEM) was developed to study two kinds of liquid addition methods in wet granulation in high shear granulator: wet binder addition (WBA) and dry binder addition (DBA). To define the complex interaction in the systems, liquid bridge model and powder penetration theory are applied to develop the contact model. The DBA system possesses ten times higher viscosity particles than the WBA system. The results of two systems were compared and differences in viscosity profile were identified. Viscous regions are found to move when time progressing. The relationship between impeller and viscosity profile are studied. The great difference in viscosity is related to strong liquid bridge force and average bridge number in the DBA system. The strong liquid bridge force results in larger granules in the DBA system.
NoteM.S.
NoteIncludes bibliographical references
Noteby Sheng-Wen Chen
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/T3319ZQS
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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