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Orbital drift, stress-free configuration, and shape memory of red blood cells in shear flow

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Title
Orbital drift, stress-free configuration, and shape memory of red blood cells in shear flow
Name (type = personal)
NamePart (type = family)
Cordasco
NamePart (type = given)
Daniel
NamePart (type = date)
1983-
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Daniel Cordasco
Role
RoleTerm (authority = RULIB)
author
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Bagchi
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Prosenjit
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Prosenjit Bagchi
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Advisory Committee
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chair
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Lin
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Hao
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Hao Lin
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Advisory Committee
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internal member
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Drazer
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German
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German Drazer
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Advisory Committee
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Shinbrot
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Troy
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Troy Shinbrot
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Advisory Committee
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outside member
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Rutgers University
Role
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degree grantor
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NamePart
Graduate School - New Brunswick
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school
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Text
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theses
OriginInfo
DateCreated (qualifier = exact)
2017
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2017-05
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2017
Place
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xx
Language
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eng
Abstract (type = abstract)
Three-dimensional numerical simulations using an immersed boundary/front-tracking method are utilized to study some novel dynamics of red blood cells (RBCs) in shear flow beyond the well-known rigid-body-like tumbling (TB) and fluid-like tank-treading (TT). These computational simulations are the first to address the following problems: (a) Orbital drift. It is shown that red blood cells may exhibit a precessing motion around the vorticity axis or a kayaking motion about the shear plane. Unlike rigid ellipsoids in Stokes flow, it is observed that deformable cells reorient their axis toward the vorticity axis or toward the shear plane depending on the initial shape, shear rate, and viscosity ratio. (b) Stress-free configuration. We consider the possibility that the resting biconcave membrane of the RBC may not be stress-free. It is shown that the assumption of stress-free shape can have a profound effect on the cell deformation and dynamics at low viscosity ratios representative of many in vitro studies. (c) Intermittency. We present the first evidence of intermittent sequences of TB and TT for deformable cells. The intermittent dynamics occur in an irregular sequence while in the synchronized dynamics TB and TT occur simultaneously with integer ratio of rotational frequencies. (d) Dynamics in oscillating shear. A comprehensive analysis of RBC motion in oscillating shear flow is performed and the existence of a chaotic motion is shown. (e) Shape memory. Lastly, we present the first 3D computational study to resolve the shape memory of RBCs in which membrane elements return to their original locations as well as global recovery of the biconcave shape after flow cessation. The timescale of recovery is orders of magnitude longer than that The timescale of recovery is orders of magnitude longer than that observed in simple stretch-relaxation experiments and is also strongly dependent on RBC stress-free configuration. The shape memory is shown to exist even when the membrane is displaced normal to the plane of shear flow.
Subject (authority = RUETD)
Topic
Mechanical and Aerospace Engineering
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Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_8063
PhysicalDescription
Form (authority = gmd)
electronic resource
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application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xxxvii, 236 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Subject (authority = ETD-LCSH)
Topic
Erythrocytes
Note (type = statement of responsibility)
by Daniel Cordasco
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
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NjNbRU
Identifier (type = doi)
doi:10.7282/T35T3P9C
Genre (authority = ExL-Esploro)
ETD doctoral
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RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Cordasco
GivenName
Daniel
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2017-04-16 14:30:39
AssociatedEntity
Name
Daniel Cordasco
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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