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Discerning the effect of salt, riboflavin and MTHFR on acute blood pressure response
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Murphy, Melissa Anne. Discerning the effect of salt, riboflavin and MTHFR on acute blood pressure response. Retrieved from https://doi.org/doi:10.7282/T3251N31

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TitleDiscerning the effect of salt, riboflavin and MTHFR on acute blood pressure response
NameMurphy, Melissa Anne (author); Miller, Joshua W. (chair); Breslin, Paul A.S. (co-chair); Shapses, Sue A. (internal member); Bello, Nicholas T. (internal member); Gow, Andrew W. (outside member); Rutgers University; Graduate School - New Brunswick
Date Created2017
Other Date2017-05 (degree)
SubjectNutritional Sciences, Blood pressure, Hypertension, Methylenetetrahydrofolate reductase
Extent1 online resource (xii, 121 p. : ill.)
DescriptionProblem: Elevated blood pressure (BP) is a top cause of mortality and leads to millions of global deaths each year; yet the cause of general hypertension (HTN) is not known. Many studies link dietary factors, particularly high sodium levels, with HTN and related cardiovascular diseases. Other studies have identified certain genes, including methylenetetrahydrofolate reductase (MTHFR) involved in folate metabolism, with a greater risk of developing HTN. Hypothesis: These studies sought to identify the impact of MTHFR genotype on the acute BP response to salt ingestion. We hypothesized that individuals would have a greater decrease in BP following salt ingestion compared to water and that this response would be diminished by the MTHFR 677TT variant allele. Methods: In an initial cohort, acute BP response was assessed, multiple times per subject, in a series of time points following an ingestion of salt or water. A secondary cohort was formed of individuals with MTHFR677 genotypes whose BP and blood were collected. Blood samples were analyzed for plasma riboflavin, homocysteine, MTHFR genotype and nitrate/nitrite levels. These data were analyzed for differences in BP response, genotypes, micronutrient status and for associations between subjects’ characteristics and BP response. Results: BP decreases within the first 60 minutes following salt ingestion. When measuring resting BP, no difference was found in BP between MTHFR genotypes. However, individuals with the 677TT variant genotype demonstrated an attenuated acute BP response to salt ingestion compared to individuals with the wild-type 677CC genotype. Conclusions: BP decreases acutely in response to salt ingestion. The MTHFR 677TT variant genotype was not associated with elevated resting BP. However, measuring acute BP response illustrated a limited response in the MTHFR variant genotype compared with the wild-type MTHFR genotype. These findings suggest that acute BP response may be a useful measure of a dynamic system, highlighting characteristics that are risk factors for HTN.
NotePh.D.
NoteIncludes bibliographical references
Noteby Melissa Anne Murphy
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/T3251N31
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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