Staff View
Application of phosphorus ligands in rhodium-catalyzed asymmetric hydroformylation and hydrogenation

Descriptive

TitleInfo
Title
Application of phosphorus ligands in rhodium-catalyzed asymmetric hydroformylation and hydrogenation
Name (type = personal)
NamePart (type = family)
Tan
NamePart (type = given)
Renchang
NamePart (type = date)
1988-
DisplayForm
Renchang Tan
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Zhang
NamePart (type = given)
Xumu
DisplayForm
Xumu Zhang
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Goldman
NamePart (type = given)
Alan
DisplayForm
Alan Goldman
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Jimenez
NamePart (type = given)
Leslie
DisplayForm
Leslie Jimenez
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Hu
NamePart (type = given)
Longqin
DisplayForm
Longqin Hu
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2017
DateOther (qualifier = exact); (type = degree)
2017-05
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2017
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Asymmetric catalysis has been playing an important role in modern synthetic chemistry. In the past decades, chiral ligands especially phosphorus chiral ligands, have demonstrated their power in transition metal catalyzed asymmetric reactions. New chiral ligands with high efficiency, selectivity and generality are always the key for the campaign of asymmetric reactions. In this dissertation, we will focus on design of new chiral phosphorus ligands and their applications in rhodium-catalyzed asymmetric hydrogenation and hydroformytation. In chapter 1, the air stable bisphosphole BIBOP ligand was applied in asymmetric hydroformylation, the new rhodium based catalytic system was demonstrated to be very effective for vinyl acetate, allyl alkenes and styrene derivatives. A new synthetic route for a chiral ╬┤-lactone via asymmetric hydroformylation was established. Computational studies were conducted for a deeper insight of the reaction mechanism. In chapter 2, a ligand library was screened for achieving rhodium catalyzed asymmetric hydroformylation of challenging 1,1-disubstituted alkenes. The BIBOP ligand successfully hydroformylated 1-(trifluoromethyl)-ethenyl acetate into a very useful precursor for drug synthesis, with good enantioselectivity. A branched product favoring approach was discovered for hydroformylation of ╬▒-(trifluoromethyl) styrene. Up to 68% ee was achieved with DuanPhos . Chapter 3 discussed the application of a novel cooperative catalyst system in asymmetric hydrogenation. Indole derivatives were hydrogenated via hydrogen bonding, with excellent enantioselectivity. The mechanistic studies supported a proton mediated tautormerization-hydrogenation sequence. Dimerization of ZhaoPhos was proposed for explaining the observed nonlinear effect.
Subject (authority = RUETD)
Topic
Chemistry and Chemical Biology
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_8021
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xii, 111 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Subject (authority = ETD-LCSH)
Topic
Hydroformylation
Note (type = statement of responsibility)
by Renchang Tan
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3Z322JK
Genre (authority = ExL-Esploro)
ETD doctoral
Back to the top

Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Tan
GivenName
Renchang
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2017-04-13 17:30:04
AssociatedEntity
Name
Renchang Tan
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2017-05-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2019-05-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after May 31st, 2019.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
Back to the top

Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
CreatingApplication
Version
1.5
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2017-04-21T11:45:26
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2017-04-21T11:45:26
ApplicationName
Microsoft® Word 2010
Back to the top
Version 8.4.8
Rutgers University Libraries - Copyright ©2022