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SWI/SNF-Mediated Lineage Determination in Mesenchymal Stem Cells Confers Resistance to Osteoporosis

Descriptive

TypeOfResource
Text
TitleInfo
Title
SWI/SNF-Mediated Lineage Determination in Mesenchymal Stem Cells Confers Resistance to Osteoporosis
Identifier (type = pmcid)
PMC5014198
Name (type = personal)
NamePart (type = family)
Nguyen
NamePart (type = given)
Kevin Hong
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Xu
NamePart (type = given)
Fuhua
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Flowers
NamePart (type = given)
Stephen
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Williams
NamePart (type = given)
Edek A.J.
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0002-6475-7622)
NamePart (type = family)
Fritton
NamePart (type = given)
J. Christopher
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Moran
NamePart (type = given)
Elizabeth
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Orthopaedics
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
New Jersey Medical School (NJMS)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Version of Record (VoR)
Note (type = peerReview)
Peer reviewed
OriginInfo
DateIssued (encoding = w3cdtf); (keyDate = yes)
2015
Abstract (type = Abstract)
Redirecting the adipogenic potential of bone marrow-derived mesenchymal stem cells to other lineages, particularly osteoblasts, is a key goal in regenerative medicine. Controlling lineage selection through chromatin remodeling complexes such as SWI/SNF, which act coordinately to establish new patterns of gene expression, would be a desirable intervention point, but the requirement for the complex in essentially every lineage pathway has generally precluded selectivity. However, a novel approach now appears possible by targeting the subset of SWI/SNF powered by the alternative ATPase, mammalian brahma (BRM). BRM is not required for development, which has hindered understanding of its contributions, but knockdown genetics here,designed to explore the hypothesis that BRM-SWI/SNF has different regulatory roles in different mesenchymal stem cell lineages, shows that depleting BRM from mesenchymal stem cells has a dramatic effect on the balance of lineage selection between osteoblasts and adipocytes. BRM depletion enhances the proportion of cells expressing markers of osteoblast precursors at the expense of cells able to differentiate along the adipocyte lineage. This effect is evident in primary bone marrow stromal cells as well as in established cell culture models. The altered precursor balance has major physiological signi´Čücance, which becomes apparent as protection against age-related osteoporosis and as reduced bone marrow adiposity in adult BRM-null mice.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
11 p.
Subject (authority = local)
Topic
SWI/SNF
Subject (authority = local)
Topic
mammalian brahma, BRM
Subject (authority = local)
Topic
Osteoblasts
Subject (authority = local)
Topic
Adipocytes
Subject (authority = local)
Topic
Mesenchymal stem cells
Subject (authority = local)
Topic
Osteoporosis
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2015
AssociatedObject
Name
Stem Cells
Type
Journal
Relationship
Has part
Detail
3028-3038
Identifier (type = volume and issue)
33
Reference (type = url)
http://dx.doi.org/10.1002/stem.2064
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedEntity
Role
Originator
Name
Elizabeth Moran
AssociatedObject
Type
Grant number
Name
R01-GM073257
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedEntity
Role
Originator
Name
J. Christopher Fritton
AssociatedObject
Type
Grant number
Name
R21-AR063351
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedEntity
Role
Originator
Name
Stephen Flowers
AssociatedObject
Type
Grant number
Name
T32-CA134268
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
NJ Health Foundation
AssociatedEntity
Role
Originator
Name
Elizabeth Moran
RelatedItem (type = host)
TitleInfo
Title
Fritton, J. Christopher
Identifier (type = local)
rucore30160500001
RelatedItem (type = host)
TitleInfo
Title
Williams, Edek A.J.
Identifier (type = local)
rucore30240700001
RelatedItem (type = host)
TitleInfo
Title
Moran, Elizabeth
Identifier (type = local)
rucore30240800001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3NC647V
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Rights

Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsDeclaration (AUTHORITY = FS); (TYPE = [FS] statement #1); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
Document
CreatingApplication
Version
1.6
ApplicationName
Adobe LiveCycle PDFG ES
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2015-09-15T09:59:13
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2015-10-08T00:21:32
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