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Zinc has insulin-mimetic properties which enhance spinal fusion in a rat model

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TypeOfResource
Text
TitleInfo
Title
Zinc has insulin-mimetic properties which enhance spinal fusion in a rat model
Name (type = personal)
NamePart (type = family)
Koerner
NamePart (type = given)
John D.
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Vives
NamePart (type = given)
Michael J.
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
O'Connor
NamePart (type = given)
J. Patrick
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Chirichella
NamePart (type = given)
Paul
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Breitbart
NamePart (type = given)
Eric A.
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Chaudhary
NamePart (type = given)
Saad B.
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Uko
NamePart (type = given)
Linda
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Subramanian
NamePart (type = given)
Sangeeta
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0002-6475-7622)
NamePart (type = family)
Fritton
NamePart (type = given)
J. Christopher
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Benevenia
NamePart (type = given)
Joseph
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Lin
NamePart (type = given)
Sheldon S.
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Orthopaedics
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
New Jersey Medical School (NJMS)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
Note (type = peerReview)
Peer reviewed
OriginInfo
DateIssued (encoding = w3cdtf); (keyDate = yes)
2016
Abstract (type = Abstract)
BACKGROUND CONTEXT: Previous studies have found that insulin or insulin-like growth factor treatment can stimulate fracture healing in diabetic and normal animal models, and increase fusion rates in a rat spinal fusion model. Insulin-mimetic agents, such as zinc, have demonstrated antidiabetic effects in animal and human studies, and these agents that mimic the effects of insulin could produce the same beneficial effects on bone regeneration and spinal fusion.

PURPOSE: The purpose of this study was to analyze the effects of locally applied zinc on spinal fusion in a rat model.

STUDY DESIGN/SETTING: Institutional Animal Care and Use Committee-approved animal study using Sprague-Dawley rats was used as the study design.

METHODS: Thirty Sprague-Dawley rats (450-500 g) underwent L4-L5 posterolateral lumbar fusion (PLF). After decortication and application of approximately 0.3 g of autograft per side, one of three pellets were added to each site: high-dose zinc calcium sulfate (ZnCaSO<sub>4</sub>), low-dose ZnCaSO4 (half of the high dose), or a control palmitic acid pellet (no Zn dose). Systemic blood glucose levels were measured 24 hours postoperatively. Rats were sacrificed after 8 weeks and the PLFs analyzed qualitatively by manual palpation and radiograph review, and quantitatively by micro-computed tomography (CT) analysis of bone volume and trabecular thickness. Statistical analyses with p-values set at .05 were accomplished with analysis of variance, followed by posthoc tests for quantitative data, or Mann-Whitney rank tests for qualitative assessments.

RESULTS: Compared with controls, the low-dose zinc group demonstrated a significantly higher manual palpation grade (p=.011), radiographic score (p=.045), and bone formation on micro-CT (172.9 mm<sup>3</sup> vs. 126.7 mm<sup>3</sup> for controls) (p<.01). The high-dose zinc also demonstrated a significantly higher radiographic score (p=.017) and bone formation on micro-CT (172.7 mm<sup>3</sup> vs. 126.7 mm<sup>3</sup>) (p<.01) versus controls, and was trending toward higher manual palpation scores (p=.058).

CONCLUSIONS: This study demonstrates the potential benefit of a locally applied insulin-mimetic agent, such as zinc, in a rat lumbar fusion model. Previous studies have demonstrated the benefits of local insulin application in the same model, and it appears that zinc has similar effects.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
19 p.
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2016
AssociatedObject
Name
The Spine Journal
Type
Journal
Relationship
Has part
Detail
777-783
Identifier (type = volume and issue)
16(6)
Reference (type = url)
http://dx.doi.org/10.1016/j.spinee.2016.01.190
Subject (authority = local)
Topic
Fusion
Subject (authority = local)
Topic
Insulin
Subject (authority = local)
Topic
Zinc
Subject (authority = local)
Topic
Insulin-mimetic
Subject (authority = local)
Topic
Mimetic
RelatedItem (type = host)
TitleInfo
Title
Fritton, J. Christopher
Identifier (type = local)
rucore30160500001
RelatedItem (type = host)
TitleInfo
Title
Vives, Michael J.
Identifier (type = local)
rucore30240900001
RelatedItem (type = host)
TitleInfo
Title
O'Connor, J. Patrick
Identifier (type = local)
rucore30241000001
RelatedItem (type = host)
TitleInfo
Title
Benevenia, Joseph
Identifier (type = local)
rucore30241400001
RelatedItem (type = host)
TitleInfo
Title
Lin, Sheldon S.
Identifier (type = local)
rucore30241500001
RelatedItem (type = host)
TitleInfo
Title
Chirichella, Paul
Identifier (type = local)
rucore30241100001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3HM5CGP
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Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsDeclaration (AUTHORITY = FS); (TYPE = [FS] statement #1); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
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Technical

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CreatingApplication
Version
1.7
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2016-06-20T16:20:13
DateCreated (point = start); (encoding = w3cdtf); (qualifier = exact)
2016-06-20T14:43:22
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