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Effects of the basic multicellular unit and lamellar thickness on osteonal fatigue life

Descriptive

TypeOfResource
Text
TitleInfo
Title
Effects of the basic multicellular unit and lamellar thickness on osteonal fatigue life
Identifier (type = pmcid)
PMC5559899
Name (type = personal)
NamePart (type = family)
Pellegrino
NamePart (type = given)
George
Affiliation
Orthopaedics; Graduate School of Biomedical Sciences, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Roman
NamePart (type = given)
Max
Affiliation
New Jersey Institute of Technology
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0002-6475-7622)
NamePart (type = family)
Fritton
NamePart (type = given)
J. Christopher
Affiliation
Orthopaedics; Graduate School of Biomedical Sciences; Biomedical Engineering, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Orthopaedics
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
New Jersey Medical School (NJMS)
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
School of Engineering
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Biomedical Engineering
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
Graduate School of Biomedical Sciences
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
Note (type = peerReview)
Peer reviewed
OriginInfo
DateIssued (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2017
Abstract (type = Abstract)
A remodeling cycle sets the size of the osteon and associated lamellae in the basic multicellular unit. Treatments and aging affect these micro-structural features. We previously demonstrated decreased fatigue life with an unexplained mechanism and decreased osteon size in cortical bone treated with high-dose bisphosphonate. Here, three finite element models were examined: type-1: a single osteon, as a homogeneous unit and with heterogeneous lamellae and interlamellae, type-2: a control, interstitial-only tissue and type-3: the osteon with cement line, set within the interstitial tissue. Models were loaded in simulated, sinusoidal bending fatigue. As osteon size was decreased, lamellar number and lamellar thickness were incrementally adjusted for each model. As hypothesized, lamellae within the larger type-1 models attained greater cycles to failure and the addition of an osteon to type-2 models (generating a type-3 model set) yielded increased fatigue life. However, as the osteon size was decreased, the potential for compressive damage nucleation was increased within the lamellae of the osteons versus the interstitium. Also, osteons with fewer, thicker lamellae displayed increased fatigue life. Osteonal microstructure plays a role in damage initiation location, especially when BMU size is smaller. Previous findings by us and others could partially be explained by this further understanding of increased probability for damage nucleation in smaller osteons.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
21 p.
Subject (authority = local)
Topic
Osteon
Subject (authority = local)
Topic
Lamella
Subject (authority = local)
Topic
Interstitium
Subject (authority = local)
Topic
Remodeling
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2017
AssociatedObject
Name
Journal of Biomechanics
Type
Journal
Relationship
Has part
Detail
116-123
Identifier (type = volume and issue)
60
Reference (type = url)
http://dx.doi.org/10.1016/j.jbiomech.2017.06.006
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedEntity
Role
Originator
Name
Fritton, J. Christopher
AssociatedObject
Type
Grant number
Name
AR063351
RelatedItem (type = host)
TitleInfo
Title
Fritton, J. Christopher
Identifier (type = local)
rucore30160500001
RelatedItem (type = host)
TitleInfo
Title
Pellegrino, George
Identifier (type = local)
rucore30240500001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3833W2D
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Rights

Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsEvent
Type
Embargo
DateTime (encoding = w3cdtf); (point = end); (qualifier = exact); (keyDate = no)
2018-06-23
DateTime (encoding = w3cdtf); (point = start); (qualifier = exact); (keyDate = no)
2017-06-23
Detail
Access to this PDF has been restricted at the publisher's request. It will be publicly available after June 23, 2018.
RightsDeclaration (AUTHORITY = FS); (TYPE = [FS] statement #1); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
Document
CreatingApplication
Version
1.4
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2017-08-17T02:41:12
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2017-08-17T02:41:12
ApplicationName
Antenna House PDF Output Library 6.3.752 (Windows (x64))
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