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Chronic High Fructose Intake Reduces Serum 1,25(OH)2D3Levels in Calcium-Sufficient Rodents

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Text
TitleInfo
Title
Chronic High Fructose Intake Reduces Serum 1,25(OH)<sub>2</sub>D<sub>3</sub>Levels in Calcium-Sufficient Rodents
Name (type = personal)
NamePart (type = family)
Douard
NamePart (type = given)
Veronique
Affiliation
Pharmacology & Physiology, Rutgers University; INRA, Domaine de Vilvert, Jouy-en-Josas, France
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Patel
NamePart (type = given)
Chirag
Affiliation
Pharmacology & Physiology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Lee
NamePart (type = given)
Jacklyn
Affiliation
Pharmacology & Physiology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Tharabenjasin
NamePart (type = given)
Phuntila
Affiliation
Pharmacology & Physiology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Williams
NamePart (type = given)
Edek A.J.
Affiliation
Biomedical Engineering, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0002-6475-7622)
NamePart (type = family)
Fritton
NamePart (type = given)
J. Christopher
Affiliation
Orthopaedics; Biomedical Engineering, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Sabbagh
NamePart (type = given)
Yves
Affiliation
Sanofi-Genzyme R&D Center, Massachusetts
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Ferraris
NamePart (type = given)
Ronaldo P.
Affiliation
Pharmacology & Physiology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Pharmacology & Physiology
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
New Jersey Medical School (NJMS)
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Biomedical Engineering
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
School of Engineering
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Orthopaedics
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Version of Record (VoR)
Note (type = peerReview)
Peer reviewed
OriginInfo
DateIssued (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2014
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
10 p.
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2014
AssociatedObject
Name
PLOS One
Type
Journal
Relationship
Has part
Identifier (type = volume and issue)
9(4)
Reference (type = url)
https://dx.doi.org/10.1371/journal.pone.0093611
Detail
e93611
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Science Foundation
AssociatedEntity
Role
Originator
Name
Ronaldo P. Ferraris
AssociatedObject
Type
Grant number
Name
IOS-1121049
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
Benjamin Delessert Foundation
AssociatedEntity
Role
Originator
Name
Veronique Douard
Abstract (type = abstract)
Excessive fructose consumption inhibits adaptive increases in intestinal Ca<sup>2</sup><sup>+</sup>transport in lactating and weanling rats with increased Ca<sup>2</sup><sup>+</sup>requirements by preventing the increase in serum levels of 1,25(OH)<sub>2</sub>D<sub>3</sub>. Here we tested the hypothesis that chronic fructose intake decreases 1,25(OH)<sub>2</sub>D<sub>3</sub> levels independent of increases in Ca<sup>2</sup><sup>+</sup> requirements. Adult mice fed for five wk a high glucose-low Ca<sup>2</sup><sup>+</sup> diet displayed expected compensatory increases in intestinal and renal Ca<sup>2</sup><sup>+</sup> transporter expression and activity, in renal CYP27B1 (coding for 1α-hydroxylase) expression as well as in serum 1,25(OH)<sub>2</sub>D<sub>3</sub> levels, compared with mice fed isocaloric glucose- or fructose-normal Ca<sup>2</sup><sup>+</sup> diets. Replacing glucose with fructose prevented these increases in Ca<sup>2</sup><sup>+</sup> transporter, CYP27B1, and 1,25(OH)<sub>2</sub>D<sub>3</sub> levels induced by a low Ca<sup>2</sup><sup>+</sup> diet. In adult mice fed for three mo a normal Ca<sup>2</sup><sup>+</sup> diet, renal expression of CYP27B1 and of CYP24A1 (24-hydroxylase) decreased and increased, respectively, when the carbohydrate source was fructose instead of glucose or starch. Intestinal and renal Ca<sup>2</sup><sup>+</sup> transporter activity and expression did not vary with dietary carbohydrate. To determine the time course of fructose effects, a high fructose or glucose diet with normal Ca<sup>2</sup><sup>+</sup> levels was fed to adult rats for three mo. Serum levels of 1,25(OH)<sub>2</sub> D<sub>3</sub> decreased and of FGF23 increased significantly over time. Renal expression of CYP27B1 and serum levels of 1,25(OH)<sub>2</sub>D<sub>3</sub> still decreased in fructose- compared to those in glucose-fed rats after three mo. Serum parathyroid hormone, Ca<sup>2</sup><sup>+</sup> and phosphate levels were normal and independent of dietary sugar as well as time of feeding. Thus, chronically high fructose intakes can decrease serum levels of 1,25(OH)<sub>2</sub>D<sub>3</sub> in adult rodents experiencing no Ca<sup>2</sup><sup>+</sup> stress and fed sufficient levels of dietary Ca<sup>2</sup><sup>+</sup>. This finding is highly significant because fructose constitutes a substantial portion of the average diet of Americans already deficient in vitamin D.
Subject
Name (authority = LCNAF)
Subject (authority = local)
Topic
Fructoses
Subject (authority = local)
Topic
Diet
Subject (authority = local)
Topic
Gastrointestinal tract
Subject (authority = local)
Topic
Glucose
Subject (authority = local)
Topic
Gene expression
Subject (authority = local)
Topic
Kidneys
Subject (authority = local)
Topic
Enzyme metabolism
Subject (authority = local)
Topic
Glucose metabolism
RelatedItem (type = host)
TitleInfo
Title
Fritton, J. Christopher
Identifier (type = local)
rucore30160500001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T30P132H
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Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers,The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee.This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work. I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others. I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsDeclaration (AUTHORITY = FS); (TYPE = [FS] statement #1); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
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RULTechMD (ID = TECHNICAL1)
ContentModel
Document
CreatingApplication
Version
1.5
ApplicationName
Acrobat Distiller 5.0 (Windows); modified using iText 5.0.3 (c) 1T3XT BVBA; modified using iText® 5.1.3 ©2000-2011 1T3XT BVBA
DateCreated (point = start); (encoding = w3cdtf); (qualifier = exact)
2014-03-27T17:39:41
DateCreated (point = start); (encoding = w3cdtf); (qualifier = exact)
2014-03-24T11:49:43
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