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Mood disorders in familial epilepsy: A test of shared etiology

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TypeOfResource
Text
TitleInfo
Title
Mood disorders in familial epilepsy: A test of shared etiology
Identifier (type = nihmsid)
NIHMS923421
Identifier (type = doi)
doi:10.7282/T3MG7SK9
Name (type = personal)
NamePart (type = family)
Insel
NamePart (type = given)
Beverly J.
Affiliation
Columbia University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Ottman
NamePart (type = given)
Ruth
Affiliation
Columbia University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0001-5859-0259)
NamePart (type = family)
Heiman
NamePart (type = given)
Gary A.
Affiliation
Genetics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Genetics
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
School of Arts and Sciences (SAS) (New Brunswick)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
Note (type = peerReview)
Peer reviewed
Note (type = special display note)
This is the accepted version of the following article: Insel BJ, Ottman R, Heiman GA. Mood disorders in familial epilepsy: A test of shared etiology. Epilepsia. 2018;00:1–9. https://doi.org/10.1111/epi.13985, which has been published in the Early View form at http://onlinelibrary.wiley.com/doi/10.1111/epi.13985/full. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/author-resources/Journal-Authors/licensing-open-access/open-access/self-archiving.html].
OriginInfo
DateIssued (encoding = w3cdtf); (keyDate = yes)
2018
Abstract (type = Abstract)
Objective: Mood disorders are the most common comorbid conditions in epilepsy but the cause remains unclear. One possible explanation is a shared genetic susceptibility to epilepsy and mood disorders. We tested this hypothesis by evaluating lifetime prevalence of mood disorders in relatives with and without epilepsy in families containing multiple individuals with epilepsy, and comparing the findings with rates from a general population sample.

Methods: The Composite International Diagnostic Interview was administered to 192 individuals from 60 families, including 110 participants with epilepsy of unknown cause (50 focal epilepsy [FE], 42 generalized epilepsy [GE], 6 FE and GE, 12 unclassifiable) and 82 relatives without epilepsy (RWOE). Odds ratios (ORs) for lifetime prevalence of mood disorders in participants with versus without epilepsy were computed through logistic regression, using generalized estimation equations to account for familial clustering. Standardized prevalence ratios (SPRs) were used to compare prevalence in family members with general population rates.

Results: Compared with RWOE, ORs for mood disorders were significantly increased in participants with FE (OR = 2.4, 95% confidence interval [CI] = 1.1 - 5.2) but not in those with GE (OR = 1.0, 95% CI = 0.4 - 2.2). In addition, prevalence of mood disorders was increased in individuals with epilepsy who had ≥1 relative with FE. Compared with general population rates, mood disorders were significantly increased in individuals with FE but not in those with GE. Rates were also increased in RWOE, but not significantly so (SPR = 1.4, P = 0.14).

Significance: These findings are consistent with the hypothesis of shared genetic susceptibility to epilepsy and mood disorders, but suggest (1) the effect may be restricted to FE, and (2) the shared genetic effect on risk of mood disorders and epilepsy may be restricted to individuals with epilepsy, that is, to those in whom the genetic risk for epilepsy is “penetrant.”
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
24 p.
Subject (authority = local)
Topic
Epilepsy
Subject (authority = local)
Topic
Mood
Subject (authority = local)
Topic
Familial
Subject (authority = local)
Topic
Shared etiology
Extension
DescriptiveEvent
Type
Citation
AssociatedObject
Name
Epilepsia
Type
Journal
Relationship
Has part
Reference (type = url)
https://doi.org/10.1111/epi.13985
Identifier (type = volume and issue)
59(2)
Detail
431-439
DateTime (encoding = w3cdtf)
2018
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedEntity
Role
Originator
Name
Gary A. Heiman
AssociatedObject
Type
Grant number
Name
K23 NS054981
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedEntity
Role
Originator
Name
Ruth Ottman
AssociatedObject
Type
Grant number
Name
NS078419
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
Epilepsy Foundation
AssociatedEntity
Role
Originator
Name
Ruth Ottman
AssociatedObject
Type
Grant number
Name
P50 HG007257
RelatedItem (type = host)
TitleInfo
Title
Heiman, Gary A.
Identifier (type = local)
rucore30131900001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Genre (authority = ExL-Esploro)
Accepted Manuscript
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RightsDeclaration (AUTHORITY = FS); (ID = rulibRdec0004); (TYPE = [FS] statement #1)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers. Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others. I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work. By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsEvent
Type
Embargo
DateTime (encoding = w3cdtf); (keyDate = no); (point = end); (qualifier = exact)
2019-01-09
DateTime (encoding = w3cdtf); (keyDate = no); (point = start); (qualifier = exact)
2018-01-09
Detail
Access to this PDF has been restricted at the publisher's request. It will be publicly available after: January 8, 2019.
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
Document
CreatingApplication
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1.7
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Microsoft® Word 2016
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2018-01-09T19:57:49
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2018-01-09T19:57:49
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