Wu, Li Bang. Novel synthesis of diaryl amine deriatives via transition-metal-free N-arylation of beta-tetralone. Retrieved from https://doi.org/doi:10.7282/T35T3PJH
DescriptionSince the word “organocatalysis” has been created by MacMillan in 2000, it has growing very fast and soon being recognized as an important category of catalysis, alongside biocatalysis and transition metal catalysis. Thanks to continuous study of these reactions, amine catalysis can now be considered as one of the methods of choice for many asymmetric functionalizations of carbonyl compounds such as aldehydes or ketones. In this dissertation, we choose diarylamines structures as our target, owing to its widely used in different field. We are going to talk about a comprehensive review of how people synthesis this kind of structure in history and provide some new ideas. With the goal of generating diversity through cascades and heteroatomic substrates, the research target was focused on efficiently conducting N-arylation via organocatalysis. By using 2-tetralone and nitrosobenzene, we truly developed an easy and effectively method to reach diarylamines in high yield. Furthermore, this reaction for sure has potential to start with more simple starting material, aniline which may be more acceptable in industrial applications.