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ZAG-1, a Zn-finger homeodomain transcription factor, affects neuronal outgrowth patterning by regulating UNC-40(DCC)-mediated outgrowth activity
Descriptive
TitleInfo
Title
ZAG-1, a Zn-finger homeodomain transcription factor, affects neuronal outgrowth patterning by regulating UNC-40(DCC)-mediated outgrowth activity
Name
(type = personal)
NamePart
(type = family)
Al-Aamiri
NamePart
(type = given)
Aseel
NamePart
(type = date)
1978-
DisplayForm
Aseel Al-Aamiri
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Wadsworth
NamePart
(type = given)
William
DisplayForm
William Wadsworth
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
School of Graduate Studies
Role
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(authority = RULIB)
school
TypeOfResource
Text
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theses
OriginInfo
DateCreated
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2017
DateOther
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(type = degree)
2017-10
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2017
Place
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(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Axon guidance is a fundamental process during animal nervous system development. For neurons to function correctly, they must be wired into their target areas. Several neurodevelopment disorders result from wiring defects. The guidance process is continuous, and outgrowth direction activity may fluctuate across the plasma membrane. We propose this process is statistically dependent. If the probability of axon outgrowth at one site changes then the probability at another site must change. The plasma membrane movement can be modeled by a random walk. Axon guidance process is regulated by many conserved extracellular guidance cues that can act as attractants or repellants, but how these guidance cues are regulated is still being researched. In Caenorhabditis elegans, the UNC-6/Netrin extracellular cue directs neuronal outgrowth. Neuronal response to UNC-6/Netrin is mediated by UNC-40/DCC and UNC-5/UNC5 receptors and the UNC-53/NAV2 cytoplasmic protein. My study provides evidence that links stochasticity with transcriptional regulation of axon guidance to regulate axon orientation at the transcriptional level. ZAG-1, a member of the ZEB family of transcription factors, affects neuronal outgrowth patterning by regulating UNC-40-mediated neuronal outgrowth activity. Understanding the functional relationship between transcription factors and the cell-surface and cytoskeletal proteins that mediate their effects is a current challenge in neurobiology. Here I present evidence that ZAG-1 and UNC-5 regulate UNC-40::GFP localization, axon outgrowth patterning, and the directional bias of axons by regulating the UNC-6/Netrin signaling pathway and UNC-53 activities. unc-5 mutations alter UNC-40::GFP asymmetric localization and axon outgrowth patterning that neurons develop. Genetic interactions suggest that UNC-5 and ZAG-1 act with UNC-53 to regulate axon outgrowth patterning and UNC-40::GFP asymmetric localization in response to extracellular guidance cues.
Subject
(authority = RUETD)
Topic
Microbiology and Molecular Genetics
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
Identifier
ETD_8349
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (x, 196 p. : ill.)
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Subject
(authority = ETD-LCSH)
Topic
Axons
Note
(type = statement of responsibility)
by Aseel Al-Aamiri
RelatedItem
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TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier
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rucore10001600001
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3H41VJ1
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Al-Aamiri
GivenName
Aseel
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(qualifier = exact);
(point = start)
2017-09-13 13:56:08
AssociatedEntity
Name
Aseel Al-Aamiri
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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windows xp
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2017-09-13T13:11:36
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