DescriptionThis analysis provides a view of homicide prevention by exploring how institutional domains create dangerous conditions of living for young black men that leave them marginalized and on the sidelines of access to high-quality education, opportunities within a legal economy, and the hope of a self-sustaining life. This research uses a case study framework to explore the persistently high prevalence of homicides of young black men and associated prevention mechanisms in inner cities in New Jersey. The cases selected center on three of New Jersey’s twelve most populated cities: Camden, Newark, and Trenton. Within each case there are two basic units of analysis; these are a set of institutional domains within each of those cities, and the population of fifteen- to twenty-four-year-old black men. The domains of interest are (a) the administration of criminal justice, (b) educational systems, (c) nonprofit agencies, and (d) public health agencies. Descriptive statistics for each of the three case study cities compared to national rates are used to inform the qualitative components, which include in-person interviews and archival analyses. Policies and recommendations are proposed with the clear purpose of changing the conditions in the lives of young black men ages fifteen to twenty-four years to reduce their marginalization from communities of people who have different Leading Causes of Death (LCOD) and are free from the need to participate in illegal economies. The recommendations are designed to move the discourse on conditions of young black men from one of discussing the victim and perpetrator, the individuals, to one of removing the dangerous and unhealthy conditions in which young black men live and die.