DescriptionBiofouling is a pervasive problem which demands the creation of smart, antifouling surfaces. Towards this end, we examine the interactions between a dipalmitoylphosphatidylcholine (DPPC) lipid bilayer and a Polyamidoamine (PAMAM) dendron-grafted surface. In addition, we investigate the impact of dendron generation on the system behavior. Our results demonstrate the system dynamics to be determined by the PAMAM dendron generation. To resolve the multiscale dynamical processes occurring over a large spatiotemporal scale, we employ Molecular Dynamics simulations with a coarse-grained implicit solvent force field. The results from our study can be used to guide the design of novel antifouling surfaces which can prevent the adsorption of microorganisms which have lipid membranes.