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Surface Errors Without Semantic Impairment in Acquired Dyslexia: A Voxel-Based Lesion-Symptom Mapping Study

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TypeOfResource
Text
TitleInfo
Title
Surface Errors Without Semantic Impairment in Acquired Dyslexia: A Voxel-Based Lesion-Symptom Mapping Study
Name (type = personal)
NamePart (type = family)
Binder
NamePart (type = given)
Jeffrey R.
Affiliation
Medical College of Wisconsin
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Pillay
NamePart (type = given)
Sara B.
Affiliation
Medical College of Wisconsin
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Humphries
NamePart (type = given)
Colin
Affiliation
Medical College of Wisconsin
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Gross
NamePart (type = given)
William L.
Affiliation
Medical College of Wisconsin
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0003-1590-2667)
NamePart (type = family)
Graves
NamePart (type = given)
William W.
Affiliation
Psychology (Newark), Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Book
NamePart (type = given)
Diane S.
Affiliation
Medical College of Wisconsin
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Psychology (Newark)
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
Newark College of Arts and Sciences
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
Note (type = peerReview)
Peer reviewed
OriginInfo
DateIssued (encoding = w3cdtf); (keyDate = yes)
2016
Abstract (type = Abstract)
Patients with surface dyslexia have disproportionate difficulty pronouncing irregularly spelled words (e.g., pint), suggesting impaired use of lexical-semantic information to mediate phonological retrieval. Patients with this deficit also make characteristic "regularization" errors, in which an irregularly spelled word is mispronounced by incorrect application of regular spelling-sound correspondences (e.g., reading plaid as "played"), indicating over-reliance on sublexical grapheme-phoneme correspondences. We examined the neuroanatomical correlates of this specific error type in 45 left hemisphere chronic stroke patients. Voxel-based lesion-symptom mapping (VLSM) showed a strong positive relationship between the rate of regularization errors and damage to the posterior half of the left middle temporal gyrus. Semantic deficits on tests of single-word comprehension were generally mild, and these deficits were not correlated with the rate of regularization errors. Furthermore, the deep occipital-temporal white matter locus associated with these mild semantic deficits was distinct from the lesion site associated with regularization errors. Thus, in contrast to patients with surface dyslexia and semantic impairment from anterior temporal lobe degeneration, surface errors in our patients were not related to a semantic deficit. We propose that these patients have an inability to link intact semantic representations with phonological representations. The data provide novel evidence for a post-semantic mechanism mediating the production of surface errors, and suggest that the posterior middle temporal gyrus may compute an intermediate representation linking semantics with phonology.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
33 p.
Subject (authority = local)
Topic
Reading
Subject (authority = local)
Topic
Alexia
Subject (authority = local)
Topic
Semantics
Subject (authority = local)
Topic
Phonology
Subject (authority = local)
Topic
Brain mapping
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2016
AssociatedObject
Name
Brain
Type
Journal
Relationship
Has part
Detail
1517-1526
Identifier (type = volume and issue)
139(5)
Reference (type = url)
https://doi.org/10.1093/brain/aww029
RelatedItem (type = host)
TitleInfo
Title
Graves, William W.
Identifier (type = local)
rucore30159500001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3HD7ZVB
Genre (authority = ExL-Esploro)
Accepted Manuscript
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RightsDeclaration (AUTHORITY = FS); (TYPE = [FS] statement #1); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
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Technical

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ContentModel
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1.5
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2015-12-30T16:54:37
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2015-12-30T16:54:37
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