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Neurally dissociable cognitive components of reading deficits in subacute stroke

Descriptive

TypeOfResource
Text
TitleInfo
Title
Neurally dissociable cognitive components of reading deficits in subacute stroke
Identifier (type = pmcid)
PMC4444825
Name (type = personal)
NamePart (type = family)
Boukrina
NamePart (type = given)
Olga
Affiliation
Psychology (Newark), Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Barrett
NamePart (type = given)
A. M.
Affiliation
Kessler Foundation
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Alexander
NamePart (type = given)
Edward J.
Affiliation
Psychology (Newark), Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Yao
NamePart (type = given)
Bing
Affiliation
Kessler Foundation
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0003-1590-2667)
NamePart (type = family)
Graves
NamePart (type = given)
William W.
Affiliation
Psychology (Newark), Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Psychology (Newark)
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
Newark College of Arts and Sciences
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Version of Record (VoR)
Note (type = peerReview)
Peer reviewed
OriginInfo
DateIssued (encoding = w3cdtf); (keyDate = yes)
2015
Abstract (type = Abstract)
According to cognitive models of reading, words are processed by interacting orthographic (spelling), phonological (sound), and semantic (meaning) information. Despite extensive study of the neural basis of reading in healthy participants, little group data exist on patients with reading deficits from focal brain damage pointing to critical neural systems for reading. Here, we report on one such study. We have performed neuropsychological testing and magnetic resonance imaging on 11 patients with left-hemisphere stroke (<=5 weeks post-stroke). Patients completed tasks assessing cognitive components of reading such as semantics (matching picture or word choices to a target based on meaning), phonology (matching word choices to a target based on rhyming), and orthography (a two-alternative forced choice of the most plausible non-word). They also read aloud pseudowords and words with high or low levels of usage frequency, imageability, and spelling-sound consistency. As predicted by the cognitive model, when averaged across patients, the influence of semantics was most salient for low-frequency, low-consistency words, when phonological decoding is especially difficult. Qualitative subtraction analyses revealed lesion sites specific to phonological processing. These areas were consistent with those shown previously to activate for phonology in healthy participants, including supramarginal, posterior superior temporal, middle temporal, inferior frontal gyri, and underlying white matter. Notable divergence between this analysis and previous functional imaging is the association of lesions in the mid-fusiform gyrus and anterior temporal lobe with phonological reading deficits. This study represents progress toward identifying brain lesion-deficit relationships in the cognitive components of reading. Such correspondences are expected to help not only better understand the neural mechanisms of reading, but may also help tailor reading therapy to individual neurocognitive deficit profiles.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
13 p.
Subject (authority = local)
Topic
MRI
Subject (authority = local)
Topic
Lesion-deficit analysis
Subject (authority = local)
Topic
Reading
Subject (authority = local)
Topic
Semantics
Subject (authority = local)
Topic
Phonology
Subject (authority = local)
Topic
Orthography
Subject (authority = local)
Topic
Stroke
Subject (authority = local)
Topic
Aphasia
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2015
AssociatedObject
Name
Frontiers in Human Neuroscience
Type
Journal
Relationship
Has part
Identifier (type = volume and issue)
9
Reference (type = url)
https://doi.org/10.3389/fnhum.2015.00298
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedEntity
Role
Originator
Name
William Graves
AssociatedObject
Type
Grant number
Name
R00- HD065839
RelatedItem (type = host)
TitleInfo
Title
Graves, William W.
Identifier (type = local)
rucore30159500001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3CR5XHW
Genre (authority = ExL-Esploro)
Journal Article
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Rights

Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsDeclaration (AUTHORITY = Creative Commons); (TYPE = Attribution (CC BY)); (ID = https://creativecommons.org/licenses/by/4.0/)
This work has been licensed by the rightsholder under a Creative Commons Attribution (CC BY) 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
Document
CreatingApplication
Version
1.6
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2015-05-26T14:22:44
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2015-05-26T14:40:56
ApplicationName
Acrobat Distiller 9.0.0 (Windows)
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