Staff View
The impact of dairy food, vitamin D and calcium consumption on women's health through the life-course

Descriptive

TitleInfo
Title
The impact of dairy food, vitamin D and calcium consumption on women's health through the life-course
Name (type = personal)
NamePart (type = family)
Gabriel
NamePart (type = given)
Susan
DisplayForm
Susan Gabriel
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Bandera
NamePart (type = given)
Elisa
DisplayForm
Elisa Bandera
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
School of Graduate Studies
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2018
DateOther (type = degree); (qualifier = exact)
2018-01
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2018
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Endometrial and ovarian cancers are hormone related cancers with the most significant risk factors being those related to high estrogen exposure, such as late age at menopause and hormone therapy use. Diet and obesity, two modifiable risk factors, have been implicated in the risk for both cancers. Early life exposures including diet, as well as early onset of puberty, may play a role in the lifetime risk of endometrial and ovarian cancers. Dairy foods, vitamin D and calcium have been implicated in endometrial and ovarian cancer risk, playing either a direct role or an indirect role through their association with body size. A major source of dietary vitamin D and calcium, dairy foods are also sources of animal derived hormones and growth factors which may have physiologic activity in humans. Obesity is a known risk factor for early sexual development in girls, possibly due to estrogen synthesis in adipose tissue. In this study, data from two population based case-control studies and baseline data from a prospective cohort study were used to examine the association between dairy foods, vitamin D and calcium with risk of endometrial cancer, ovarian cancer, and early breast development and body size in pre-pubertal girls, respectively. Endometrial cancer risk was significantly inversely associated with dietary calcium intake in our study. Among post menopausal women, high versus low intake of total calcium was associated with significantly lower risk of endometrial cancer. Less frequent consumption of low-fat cheese was associated with significantly greater risk of endometrial cancer compared to frequent consumption of low-fat type. Effect modification was found by hormone therapy use for total calcium and risk of endometrial cancer, with ‘ever’ users having greater risk compared to ‘never’ users. Milk intake was significantly associated with ovarian cancer risk; significant effect modification by hormone therapy use was found for the association between ovarian cancer risk and total vitamin D intake, with ‘ever’ users having lower risk estimates versus ‘never’ users. Higher dietary calcium intake was associated with lower mean BMI, fat mass and percent body fat among young girls, while higher total milk and dairy intake were associated with higher adiposity measures. Girls in the highest tertile of total milk were significantly more likely to be overweight and above, as were those in the middle tertile of dietary calcium. In conclusion, our results suggest a possible protective role for calcium with risk of endometrial cancer and reduced adiposity in young girls, and an increased risk for ovarian cancer risk with milk intake. Future research should build on these findings by further elucidating calcium’s role in endometrial and ovarian cancer risk and body size in young girls through larger studies focused on high risk populations (i.e., obese and post-menopausal women, young girls) as well as associations with epithelial ovarian cancer tumor sub-types.
Subject (authority = RUETD)
Topic
Public Health
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_8652
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (vii, 70 p.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Subject (authority = ETD-LCSH)
Topic
Ovaries--Cancer
Note (type = statement of responsibility)
by Susan Gabriel
RelatedItem (type = host)
TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier (type = local)
rucore10001600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T31N84B4
Back to the top

Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Gabriel
GivenName
Susan
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2018-01-10 18:08:14
AssociatedEntity
Name
Susan Gabriel
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2018-01-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2019-01-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after January 31st, 2019.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
Back to the top

Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
CreatingApplication
Version
1.5
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2018-01-10T06:32:37
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2018-01-10T06:32:37
ApplicationName
Microsoft® Word 2010
Back to the top
Version 8.3.10
Rutgers University Libraries - Copyright ©2019