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One-pot hydrothermally synthesized mesostructured silicas for effective controlled drug-release applications
Descriptive
TitleInfo
Title
One-pot hydrothermally synthesized mesostructured silicas for effective controlled drug-release applications
Name
(type = personal)
NamePart
(type = family)
Ganti
NamePart
(type = given)
Anjani
NamePart
(type = date)
1991-
DisplayForm
Anjani Ganti
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Asefa
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(type = given)
Tewodros
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Tewodros Asefa
Affiliation
Advisory Committee
Role
RoleTerm
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chair
Name
(type = personal)
NamePart
(type = family)
Dutt
NamePart
(type = given)
Meenakshi
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Meenakshi Dutt
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Hara
NamePart
(type = given)
Masanori
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Masanori Hara
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
School of Graduate Studies
Role
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school
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Text
Genre
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theses
OriginInfo
DateCreated
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2018
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(type = degree)
2018-01
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2018
Place
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xx
Language
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(type = code)
eng
Abstract
(type = abstract)
Mesoporous silica nanoparticles (MSNs) have captured the interest of researchers worldwide due to their unique properties (e.g., high surface area, uniform pores with tunable pore sizes) and application in various fields such as catalysis, drug delivery systems (DDS), etc. In particular, they offer numerous advantages over traditional nano-based formulations in the development of DDS. However, there are few key challenges involved with developing efficient DDS (such as achieving a high drug loading capacity and cost-effective manufacturing of the DDS). Drug-loaded mesostructured silica nanoparticles are typically synthesized in a two-step fashion – the first step involving synthesis of MSNs and the second step entailing the loading of drug into MSNs via physical adsorption of highly concentrated drug solutions onto the mesoporous framework. The current project aims to synthesize a novel DDS for controlled release antimicrobial drug delivery applications that employs the active drug as template in a facile single-step hydrothermal synthesis process, thereby addressing the above mentioned key challenges. Quaternary ammonium compounds (QACs) have been shown to exhibit broad-spectrum antimicrobial activity. In this work, mesostructured silica nanoparticles were synthesized by employing three different QACs - didecyldimethylammonium chloride (DDAC), cetylpyridinium chloride (CPC) and benzalkonium chloride (BAC) – as templates. Initial surface area measurements by physical adsorption of N2 gas on the three synthesized materials indicated the BAC-templated material to be having a high surface area (ca. 1,500 m2/g). Further characterization tests were carried out on this selected material in order to get a better understanding of its properties and also to investigate its potential usage as a DDS for antimicrobial applications. Drug release studies were carried out at physiologically relevant pH levels (5-8) to demonstrate the pH-responsive controlled release of BAC, and the results have been discussed. Microbiological assays demonstrate a significant time-dependent reduction in Staphylococcus aureus and Salmonella enterica viability.
Subject
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Topic
Chemical and Biochemical Engineering
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
Identifier
ETD_8615
PhysicalDescription
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electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (viii, 35 p. : ill.)
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Subject
(authority = ETD-LCSH)
Topic
Drug delivery systems
Subject
(authority = ETD-LCSH)
Topic
Mesoporous materials
Note
(type = statement of responsibility)
by Anjani Ganti
RelatedItem
(type = host)
TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier
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rucore10001600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3XS5ZKH
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Ganti
GivenName
Anjani
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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2018-01-04 15:43:54
AssociatedEntity
Name
Anjani Ganti
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
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ETD
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windows xp
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1.4
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2018-01-04T15:41:01
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2018-01-04T15:41:01
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