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Neural correlates of cue-induced cocaine seeking in the nucleus accumbens of long-evans rats

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TitleInfo
Title
Neural correlates of cue-induced cocaine seeking in the nucleus accumbens of long-evans rats
Name (type = personal)
NamePart (type = family)
Kulik
NamePart (type = given)
Julianna
NamePart (type = date)
1984-
DisplayForm
Julianna Kulik
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
West
NamePart (type = given)
Mark
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Mark West
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Advisory Committee
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chair
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Bieszczad
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Katarzyna
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Katarzyna Bieszczad
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Advisory Committee
Role
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internal member
Name (type = personal)
NamePart (type = family)
Kusnecov
NamePart (type = given)
Alexander
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Alexander Kusnecov
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Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Aston-Jones
NamePart (type = given)
Gary
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Gary Aston-Jones
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
School of Graduate Studies
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2018
DateOther (qualifier = exact); (type = degree)
2018-01
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2018
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Male and female Long-Evans rats were trained to self-administer (SA) cocaine in a two-week SA experiment. Availability of cocaine was signaled by a discrete tone cue and drug administration was contingent upon a nose-poke response during the period when the tone was presented. Firing rates on trials preceding the first infusion (missed opportunities), were compared to the trial immediately leading to first self-administered infusion (first hit). When movement-free, tone-evoked, firing rates of core and shell neurons were analyzed, it was observed that both core and shell showed robust task-related changes in firing. NAc neurons of both males and females showed differences in tone-evoked firing between all of the missed trials prior to the first infusion, vs the first hit of the day. Consistent with learning by core and shell neurons of association between tone and cocaine, only late sessions showed the difference between missed trials and the tone immediately leading to the first self-administered infusion of the day. For males the effect of neuron subregion did not modify the neural response to “Hits” vs “Misses”, whereas for females there was a major increase for shell neurons, however only to “Missed” trials. Together these results suggest that the core is not the first and only stage of processing of limbic inputs necessary for cue-induced drug seeking in nucleus accumbens, but rather processing of those cues might involve NAc shell, which is anatomically upstream of the core.
Subject (authority = RUETD)
Topic
Psychology
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Title
Rutgers University Electronic Theses and Dissertations
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ETD
Identifier
ETD_8684
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electronic resource
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application/pdf
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text/xml
Extent
1 online resource (viii, 79 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Julianna Kulik
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TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier (type = local)
rucore10001600001
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/T3WM1HM1
Genre (authority = ExL-Esploro)
ETD doctoral
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The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Kulik
GivenName
Julianna
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2018-01-17 10:49:52
AssociatedEntity
Name
Julianna Kulik
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
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Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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