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Micro-3D printing of bio-inspired microneedle with enhanced adhesion capabilities
Descriptive
TitleInfo
Title
Micro-3D printing of bio-inspired microneedle with enhanced adhesion capabilities
Name
(type = personal)
NamePart
(type = family)
Morde
NamePart
(type = given)
Riddish Sudhir
NamePart
(type = date)
1992-
DisplayForm
Riddish Sudhir Morde
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Lee
NamePart
(type = given)
Dr. Howon
DisplayForm
Dr. Howon Lee
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
School of Graduate Studies
Role
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school
TypeOfResource
Text
Genre
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theses
OriginInfo
DateCreated
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2018
DateOther
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2018-01
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2018
Place
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xx
Language
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eng
Abstract
(type = abstract)
Microneedles (MNs) are an array of micron-sized needles that have been used as an excellent alternative to invasive and painful hypodermic needles. Due to their micro-scale structure, MNs can overcome the skin barrier without causing significant pain to the patient. Micro-Electro-Mechanical system (MEMS) fabrication techniques have led to the promising applications of MNs in biomedical field such as drug delivery and transdermal bio sensing. However, current fabrication techniques for MNs are complicated and time consuming. Another challenge is to achieve significant tissue adhesion over long periods. Inspired by porcupine quill and honeybee stinger where intricate side profiles promote adhesion to the skin tissue, here we present a micro 3D printed bio-inspired microneedle with backward-facing curved fins. With this side-profile on the MN, the adhesion force is significantly enhanced due to mechanical interlocking of the fins to the skin tissue. To create backward-facing fins on the side of microneedle, we utilize photo-crosslinking density gradient of the polymer to induce curvature in the fins that are horizontally attached to MNs. When such a microneedle is inserted into the skin, the curved fins extruded from the microneedle surface create mechanical interlocking with the skin tissues, resulting in enhanced adhesion of the needles. Geometrical parameters of fins including number of fins, pitch and length is studied to determine optimal configuration to maximize the adhesion performance of the microneedle. Piercing/pull-out test showed adhesion force of single MN per unit area of 2.66 ± 0.33 N/cm2 showing ~20 times higher adhesion force to the tissue compared to microneedles without fins. This unique design of bio-inspired microneedle with enhanced adhesion capability has potential to be used for various transdermal applications such as transdermal drug delivery and transdermal bio-sensing.
Subject
(authority = RUETD)
Topic
Mechanical and Aerospace Engineering
Subject
(authority = ETD-LCSH)
Topic
Three-dimensional printing
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Title
Rutgers University Electronic Theses and Dissertations
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Identifier
ETD_8653
PhysicalDescription
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electronic resource
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application/pdf
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text/xml
Extent
1 online resource (ix, 60 p. : ill.)
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Riddish Sudhir Morde
RelatedItem
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TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier
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rucore10001600001
Location
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NjNbRU
Identifier
(type = doi)
doi:10.7282/T39P34VS
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Morde
GivenName
Riddish
MiddleName
Sudhir
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(qualifier = exact);
(point = start)
2018-01-11 11:55:24
AssociatedEntity
Name
Riddish Morde
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
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(qualifier = exact);
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2018-01-31
DateTime
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2019-01-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after January 31st, 2019.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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windows xp
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2018-01-19T14:57:04
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