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Combined feedforward/feedback control of an integrated continuous granulation process
Descriptive
TitleInfo
Title
Combined feedforward/feedback control of an integrated continuous granulation process
Name
(type = personal)
NamePart
(type = family)
Pereira
NamePart
(type = given)
Glinka Cathy
NamePart
(type = date)
1993-
DisplayForm
Glinka Cathy Pereira
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Singh
NamePart
(type = given)
Ravendra
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Ravendra Singh
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Ramachandran
NamePart
(type = given)
Rohit
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Rohit Ramachandran
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Ierapetritou
NamePart
(type = given)
Marianthi
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Marianthi Ierapetritou
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
School of Graduate Studies
Role
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school
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Text
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theses
OriginInfo
DateCreated
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2018
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2018-01
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2018
Place
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xx
Language
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eng
Abstract
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Continuous pharmaceutical manufacturing (CPM) offers shorter processing times and increased product quality assurance, among several other advantages which makes it an ever growing interest among pharmaceutical companies. A suitable efficient control system is however desired for CPM to achieve a consistent predefined end product quality. The feedforward controller measures and takes corrective actions for disturbances proactively before they affect the process and thereby product quality. The feedback controller considers the real time deviation of control variable from pre-specified set point and keeps it at a minimum possible value. The deviation of a control variable from the set point could be because of both measurable and unmeasurable disturbances. In order to control product quality more accurately, the effects of input disturbances need to be proactively mitigated. Therefore, it is desired that a combined feedforward/feedback control system integrated with suitable Process Analytical Technology (PAT) be implemented over a traditional feedback-only control system. In this work, an advanced combined control strategy has been developed for a continuous twin screw wet granulation (WG) process. A pre-blend of the active pharmaceutical ingredient (API) and intragranular components is fed into the continuous twin screw granulator (TSG), together with second stream containing excipient. Lack of homogeneity of the active ingredient in the pre-blend stream is a major source of variability in the process. Negligible back mixing within the granulator ensures that the input variability exits the granulator unfiltered and is manifested as content non-uniformity in the granules. An integrated flowsheet was developed and simulated in order to evaluate the effect of control loops on critical quality attributes (CQAs). Different strategies of manipulation have been evaluated and the best strategy was identified. In silico study on the combined feedforward/feedback control strategy and feedback-only control strategy demonstrates that the combined loop results in diminished variability of the CQAs. Different control algorithms were then evaluated and the best control algorithm was successfully implemented in the pilot plant.
Subject
(authority = RUETD)
Topic
Chemical and Biochemical Engineering
Subject
(authority = ETD-LCSH)
Topic
Granulation
Subject
(authority = ETD-LCSH)
Topic
Pharmaceutical industry
RelatedItem
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Title
Rutgers University Electronic Theses and Dissertations
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ETD
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ETD_8577
PhysicalDescription
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electronic resource
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application/pdf
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text/xml
Extent
1 online resource (xi, 79 p. : ill.)
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Glinka Cathy Pereira
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TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier
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rucore10001600001
Location
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NjNbRU
Identifier
(type = doi)
doi:10.7282/T3M048N1
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Pereira
GivenName
Glinka
MiddleName
Cathy
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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2017-12-20 10:28:50
AssociatedEntity
Name
Glinka Pereira
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
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2018-01-31
DateTime
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2018-08-02
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after August 2nd, 2018.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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2017-12-20T02:32:52
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