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Inhibition of histone deacetylase 3 via RGFP966 facilitates exceptionally specific and enduring memory for excitatory and inhibitory sound-signal associations

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TitleInfo
Title
Inhibition of histone deacetylase 3 via RGFP966 facilitates exceptionally specific and enduring memory for excitatory and inhibitory sound-signal associations
Name (type = personal)
NamePart (type = family)
Shang
NamePart (type = given)
Andrea
DisplayForm
Andrea Shang
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Bieszczad
NamePart (type = given)
Kasia
DisplayForm
Kasia Bieszczad
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
School of Graduate Studies
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2018
DateOther (qualifier = exact); (type = degree)
2018-01
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2018
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Epigenetic mechanisms that modulate gene expression are key to regulating long-term memory (LTM) formation, and are known to exert control on memory formation in multiple systems of the adult brain, including the sensory cortex. Chromatin modifications have been shown to have powerful effects on experience-dependent transcription for neuroplasticity underlying memory processes. One mechanism for chromatin modification is histone acetylation. Histone acetyltransferases (HATs) generally facilitate LTM formation by promoting gene expression, while histone deacetylases (HDACs) tend to have gene silencing effects, and negatively regulate LTM. Thus, blocking the action of HDACs has been shown to facilitate LTM formation. Because sensory cortex undergoes learning-induced remodeling over a lifetime, here we aimed to identify the ways in which HDAC-inhibition acts to facilitate LTM using a standard model of auditory memory and cortical plasticity. Auditory cortical plasticity in particular has been extensively studied in learning and memory processes. Representational plasticity in primary auditory cortex (A1) is known to reflect the formation of strong and sound-selective associative memory for behaviorally relevant sound features. In this present study, we used RGFP966, a class I HDAC inhibitor with selectivity for HDAC3 that has been shown to modulate associative learning-induced A1 plasticity (Bieszczad et al., 2015), to facilitate memory consolidation in rats learning a 2-tone sound frequency discrimination (2TD) task. We found that systemic treatments of the HDAC3-inhibitor early in 2TD task training facilitated associative learning for both excitatory (CS+) and inhibitory (CS-) sound signals, and altered the LTM formed in two ways that were independent of the final performance level achieved, which was equivalent between groups. We found that HDAC3-inhibition enhanced memory specificity for the sound-frequency of the two pure-tone CS cues, and strengthened memory for the excitatory and inhibitory sound-specific associations. Moreover, the behavioral effects of an initial, limited bout of HDAC3-inhibitor were long-lasting, enduring for at least weeks following the last administration of RGFP966. The present results support a role for HDAC3 during auditory memory consolidation by regulating the specificity and strength of newly learned sound-signal associations. This conclusion complements existing research on the effects of HDAC-inhibitors by providing a potential behavioral explanation for long-term memory enhancements.
Subject (authority = RUETD)
Topic
Psychology
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_8623
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (vi, 47 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Subject (authority = ETD-LCSH)
Topic
Learning
Subject (authority = ETD-LCSH)
Topic
Memory
Note (type = statement of responsibility)
by Andrea Shang
RelatedItem (type = host)
TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier (type = local)
rucore10001600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T35M68W3
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Shang
GivenName
Andrea
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2018-01-05 19:55:26
AssociatedEntity
Name
Andrea Shang
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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ETD
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windows xp
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DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2018-01-19T03:22:29
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2018-01-19T03:22:29
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