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Association of PIK3CA and PTEN genetic alterations with cervical cancer mortality and tumor recurrence
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Odekunle, Florence Femi. Association of PIK3CA and PTEN genetic alterations with cervical cancer mortality and tumor recurrence. Retrieved from https://doi.org/doi:10.7282/T3KD228P

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TitleAssociation of PIK3CA and PTEN genetic alterations with cervical cancer mortality and tumor recurrence
NameOdekunle, Florence Femi (author); Coffman, Frederick (chair); Srinivasan, Shankar (internal member); Mitrofanova, Antonina (internal member); Rutgers University; School of Health Professions
Date Created2018
Other Date2018-05 (degree)
SubjectBiomedical Informatics, Cervix uteri--Cancer
Extent1 online resource (xiv, 126 p. : ill.)
DescriptionBackground: Despite the fact that cervical cancer is known to be a preventable cancer, it remains one of the major causes of cancer-related deaths in females. A number of studies have attributed differences in clinical outcomes of cervical cancer to several factors such as stage at presentation, treatment pattern, and socioeconomic status. However, the association of specific genetic alterations with differences in clinical outcomes remains largely unexplored. Objectives: The initial research purpose was to identify the most common oncogene and tumor suppressor gene in cervical cancer with mutations and copy number alterations (CNAs). The focused research purpose was to examine the association of the identified oncogene and tumor suppressor gene with clinical outcomes and racial differences. Methodology: This study made use of the Cancer Genome Atlas (TCGA) database. The TCGA cervical cancer data were submitted between 2011 and 2014. The two genomic profiles used were mutation data and CNA data. The Fisher’s exact and chi-square tests were used to test for associations between the categorical variables. Logistic regression analysis was used to quantify the strength of associations.   Results: There were 309 cervical cancer cases. Phosphatidylinositol3-Kinase Catalytic Subunit Alpha (PIK3CA) and Phosphatase and Tensin Homolog (PTEN) genes were identified as the most common oncogene and tumor suppressor gene respectively. 63 patients had mutations in PIK3CA or PTEN or both, and 70 patients had CNAs. The ORs (Exp(B)) of death and tumor recurrence for patients with mutations were 3.300(1.625– 6.700) and 2.461(1.120–5.407) respectively. The ORs of death and tumor recurrence for patients with CNAs were 2.316(1.282–4.186) and 2.383(1.228–4.624) respectively. The ORs for CNA positive for the Black race compared to White race was 2.378(1.137–5.452). Conclusions: Genetic alterations in PIK3CA or PTEN or both are associated with a higher risk of cervical cancer mortality and tumor recurrence. These genes can be explored as therapeutic targets to improve cervical cancer treatment. High prevalence of CNAs in African American women could be due to the fact that a larger percentage presented at a later stage as stages III and IV are significant predictors of the presence of CNAs in these genes.
NotePh.D.
NoteIncludes bibliographical references
Noteby Florence Femi Odekunle
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/T3KD228P
Languageeng
CollectionSchool of Health Professions ETD Collection
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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