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Association of PIK3CA and PTEN genetic alterations with cervical cancer mortality and tumor recurrence

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TitleInfo
Title
Association of PIK3CA and PTEN genetic alterations with cervical cancer mortality and tumor recurrence
Name (type = personal)
NamePart (type = family)
Odekunle
NamePart (type = given)
Florence Femi
NamePart (type = date)
1973-
DisplayForm
Florence Femi Odekunle
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Coffman
NamePart (type = given)
Frederick
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Frederick Coffman
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Srinivasan
NamePart (type = given)
Shankar
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Shankar Srinivasan
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Mitrofanova
NamePart (type = given)
Antonina
DisplayForm
Antonina Mitrofanova
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
School of Health Professions
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2018
DateOther (qualifier = exact); (type = degree)
2018-05
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2018
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Background: Despite the fact that cervical cancer is known to be a preventable cancer, it remains one of the major causes of cancer-related deaths in females. A number of studies have attributed differences in clinical outcomes of cervical cancer to several factors such as stage at presentation, treatment pattern, and socioeconomic status. However, the association of specific genetic alterations with differences in clinical outcomes remains largely unexplored. Objectives: The initial research purpose was to identify the most common oncogene and tumor suppressor gene in cervical cancer with mutations and copy number alterations (CNAs). The focused research purpose was to examine the association of the identified oncogene and tumor suppressor gene with clinical outcomes and racial differences. Methodology: This study made use of the Cancer Genome Atlas (TCGA) database. The TCGA cervical cancer data were submitted between 2011 and 2014. The two genomic profiles used were mutation data and CNA data. The Fisher’s exact and chi-square tests were used to test for associations between the categorical variables. Logistic regression analysis was used to quantify the strength of associations.   Results: There were 309 cervical cancer cases. Phosphatidylinositol3-Kinase Catalytic Subunit Alpha (PIK3CA) and Phosphatase and Tensin Homolog (PTEN) genes were identified as the most common oncogene and tumor suppressor gene respectively. 63 patients had mutations in PIK3CA or PTEN or both, and 70 patients had CNAs. The ORs (Exp(B)) of death and tumor recurrence for patients with mutations were 3.300(1.625– 6.700) and 2.461(1.120–5.407) respectively. The ORs of death and tumor recurrence for patients with CNAs were 2.316(1.282–4.186) and 2.383(1.228–4.624) respectively. The ORs for CNA positive for the Black race compared to White race was 2.378(1.137–5.452). Conclusions: Genetic alterations in PIK3CA or PTEN or both are associated with a higher risk of cervical cancer mortality and tumor recurrence. These genes can be explored as therapeutic targets to improve cervical cancer treatment. High prevalence of CNAs in African American women could be due to the fact that a larger percentage presented at a later stage as stages III and IV are significant predictors of the presence of CNAs in these genes.
Subject (authority = RUETD)
Topic
Biomedical Informatics
Subject (authority = ETD-LCSH)
Topic
Cervix uteri--Cancer
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_8906
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xiv, 126 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Florence Femi Odekunle
RelatedItem (type = host)
TitleInfo
Title
School of Health Professions ETD Collection
Identifier (type = local)
rucore10007400001
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/T3KD228P
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Odekunle
GivenName
Florence
MiddleName
Femi
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2018-04-16 14:18:43
AssociatedEntity
Name
Florence Odekunle
Role
Copyright holder
Affiliation
Rutgers University. School of Health Professions
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2018-04-19T17:39:37
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2018-04-19T17:39:37
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