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Temporal control of encapsulant release from nanoparticle loaded polymersomes via single pulse irradiation

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TitleInfo
Title
Temporal control of encapsulant release from nanoparticle loaded polymersomes via single pulse irradiation
Name (type = personal)
NamePart (type = family)
DiSalvo
NamePart (type = given)
Gina Marie
NamePart (type = date)
1988-
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Gina Marie DiSalvo
Role
RoleTerm (authority = RULIB)
author
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Brannigan
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Grace
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Grace Brannigan
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Advisory Committee
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chair
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NamePart (type = family)
O'Malley
NamePart (type = given)
Sean M
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Sean M O'Malley
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Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Griepenburg
NamePart (type = given)
Julianne C
DisplayForm
Julianne C Griepenburg
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Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Kumi
NamePart (type = given)
George
DisplayForm
George Kumi
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Arbuckle-Keil
NamePart (type = given)
Georgia
DisplayForm
Georgia Arbuckle-Keil
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Camden Graduate School
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
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theses
OriginInfo
DateCreated (qualifier = exact)
2018
DateOther (qualifier = exact); (type = degree)
2018-05
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2018
Place
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xx
Language
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eng
Abstract (type = abstract)
Polymersomes are spherical vesicles that self-assemble from amphiphilic diblock copolymers. Their structure is comprised of a bilayer membrane and an aqueous lumen which have the ability to encapsulate hydrophobic and hydrophilic molecules, respectively. Polymersomes have received significant attention for applications in drug delivery due to their ability to control the time and location of drug release within the body; this is highly desirable in that potential side effects associated with non-specific cytotoxic drugs can be minimized. While a variety of different stimuli to initiate cargo release have been investigated, light is a particularly attractive trigger because it can be minimally damaging yet deeply penetrating at certain wavelengths and intensities. In order to reduce the dosage of light required to initiate membrane disruption, photosensitizers must be incorporated into the system. In this work, hydrophobic gold nanoparticles (AuNPs) are incorporated into the membrane of PBD35-b-PEG20 (polybutadiene(1,2 addition)-b-ethyleneoxide) polymersomes. Photosensitization is brought about by the strong optical absorption associated with the plasmonic nature of the particles and the accompanying photo- and thermal-mechanical phenomena produced upon excitation. Both nanosecond and femtosecond pulsed laser sources, tuned to a wavelength congruent with the localized surface plasmon resonance (SPR) of the incorporated AuNPs, were used to trigger encapsulant release. Herein, the interaction of single pulse laser irradiation on an individual polymersome basis has been explored. Incorporation of AuNPs in the membrane are shown to significantly reduce the rupture threshold energy for both pulse widths when compared to empty membranes. Additionally, irradiation with sub-threshold energies resulted in the formation of membrane pores with encapsulant release occurring over a time frame of two minutes. An analytical model for drug release from circular membrane pores was used to determine effective pore radii in the irradiated vesicles. Preliminary work to scale down the system to the nanoscale for use as a drug delivery system in vivo is also shown. This fundamental study demonstrates the ability to control encapsulant release from photosensitive polymersomes in a highly spatial and temporal manner.
Subject (authority = RUETD)
Topic
Chemistry
Subject (authority = ETD-LCSH)
Topic
Nanoparticles
Subject (authority = ETD-LCSH)
Topic
Polymers
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_8993
PhysicalDescription
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electronic resource
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application/pdf
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text/xml
Note
Supplementary File: Figure 13
Extent
1 online resource (viii, 51 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Gina Marie Disalvo
RelatedItem (type = host)
TitleInfo
Title
Camden Graduate School Electronic Theses and Dissertations
Identifier (type = local)
rucore10005600001
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/T3SF30HK
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
DiSalvo
GivenName
Gina
MiddleName
Marie
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2018-04-30 21:32:16
AssociatedEntity
Name
Gina DiSalvo
Role
Copyright holder
Affiliation
Rutgers University. Camden Graduate School
AssociatedObject
Type
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Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2018-05-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2019-05-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after May 31st, 2019.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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