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Oligomerization of nicotinic acetylcholine receptors in membranes with DHA-enriched domains

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TitleInfo
Title
Oligomerization of nicotinic acetylcholine receptors in membranes with DHA-enriched domains
Name (type = personal)
NamePart (type = family)
Woods
NamePart (type = given)
Kristen N.
NamePart (type = date)
1993-
DisplayForm
Kristen N. Woods
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Brannigan
NamePart (type = given)
Jessica Grace
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Jessica Grace Brannigan
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Klein
NamePart (type = given)
Eric
DisplayForm
Eric Klein
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Martin
NamePart (type = given)
Joseph
DisplayForm
Joseph Martin
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Camden Graduate School
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2018
DateOther (qualifier = exact); (type = degree)
2018-05
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2018
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
The nicotinic acetylcholine receptor (nAChR) is an excitatory neurotransmitter receptor that mediates muscle functioning by forming nAChR-associated, lattice networks. At the neuromuscular junction (NMJ), synaptic and intracellular proteins, notably Agrin, MusK, and rapsyn, ultimately stabilize these highly dense networks. Interestingly, experimental evidence suggests that cholesterol-rich domains, known as lipid rafts, facilitate signaling among Agrin-Musk and rapsyn, and their presence is essential for healthy nAChR clustering. In spite of their importance, the structural and functional mechanisms of lipid domains are currently unknown. Alongside cholesterol, Docosahexaenoic acid omega-3 fatty acids (DHA-PUFAs) are prevalent at the NMJ, correlate with domain formation, and strongly promote neuronal health. In the present study, we computationally explored the role of DHA-PUFAs on nAChR clustering in the presence and absence of lipid domains. Within coarse-grained (CG) model membranes, nAChRs consistently partitioned into flexible, liquid-disordered domains; boundary lipids were rich in DHA-PUFAs regardless of the number of nAChR molecules, but preventing domain formation also reduced the likelihood of these acyl chains aggregating around nAChR. Taken together, our findings suggest that by inducing domain formation in membranes, DHA plays a critical role in the early stages of nAChR oligomerization.
Subject (authority = RUETD)
Topic
Computational and Integrative Biology
Subject (authority = ETD-LCSH)
Topic
Unsaturated fatty acids
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_9007
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (v, 33 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Kristen N. Woods
RelatedItem (type = host)
TitleInfo
Title
Camden Graduate School Electronic Theses and Dissertations
Identifier (type = local)
rucore10005600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3G1646D
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Woods
GivenName
Kristen
MiddleName
N.
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2018-05-01 15:01:57
AssociatedEntity
Name
Kristen Woods
Role
Copyright holder
Affiliation
Rutgers University. Camden Graduate School
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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2018-05-02T20:57:35
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2018-05-02T17:00:01
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