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The effects of estrogen deficiency on cortical bone microporosity and mineralization

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TypeOfResource
Text
TitleInfo
Title
The effects of estrogen deficiency on cortical bone microporosity and mineralization
Name (type = personal)
NamePart (type = family)
Sharma
NamePart (type = given)
Divya
Affiliation
The City College of New York
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Larriera
NamePart (type = given)
Adriana I.
Affiliation
The City College of New York
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Palacio-Mancheno
NamePart (type = given)
Paolo E.
Affiliation
The City College of New York
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Gatti
NamePart (type = given)
Vittorio
Affiliation
The City College of New York
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal); (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (valueURI = http://orcid.org/0000-0002-6475-7622)
NamePart (type = family)
Fritton
NamePart (type = given)
J. Christopher
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Bromage
NamePart (type = given)
Timothy G.
Affiliation
New York University College of Dentistry
Role
RoleTerm (type = text); (authority = marcrt)
Name (type = personal)
NamePart (type = family)
Cardoso
NamePart (type = given)
Luis
Affiliation
The City College of New York
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Doty
NamePart (type = given)
Stephen B.
Affiliation
Hospital for Special Surgery
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Fritton
NamePart (type = given)
Susannah P.
Affiliation
The City College of New York
Role
RoleTerm (type = text); (authority = marcrt)
Name (type = corporate); (authority = RutgersOrg-Department)
NamePart
Orthopaedics
Name (type = corporate); (authority = RutgersOrg-School)
NamePart
New Jersey Medical School (NJMS)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
Note (type = peerReview)
Peer reviewed
OriginInfo
DateIssued (encoding = w3cdtf); (keyDate = yes)
2018
Abstract (type = Abstract)
Recent studies have demonstrated matrix-mineral alterations in bone tissue surrounding osteocytes in estrogen-deficient animals.While cortical bone porosity has been shown to be a contributor to the mechanical properties of bone tissue, little analysis has been done to investigate the effects of estrogen deficiency on bone's microporosities, including the vascular and osteocyte lacunar porosities. In this study we examined alterations in cortical bone microporosity, mineralization, and cancellous bone architecture due to estrogen deficiency in the ovariectomized rat model of postmenopausal osteoporosis. Twenty-week-old female Sprague–Dawley rats were subjected to either ovariectomy or sham surgery. Six weeks post-surgery tibiae were analyzed using high-resolution micro-CT, backscattered electron imaging, nanoindentation, and dynamic histomorphometry. Estrogen deficiency caused an increase in cortical bone vascular porosity, with enlarged vascular pores and little change in tissue mineral density in the proximal tibial metaphysis. Measurements of cancellous architecture corresponded to previous studies reporting a decrease in bone volume fraction, an increase in trabecular separation, and a decrease in trabecular number in the proximal tibia due to estrogen deficiency. Nanoindentation results showed no differences in matrix stiffness in osteocyte-rich areas of the proximal tibia of estrogen-deficient rats, and bone labeling and backscattered electron imaging showed no significant changes in mineralization around the vascular pores. The findings demonstrate local surface alterations of vascular pores due to estrogen deficiency. An increase in cortical vascular porosity may diminish bone strength as well as alter bone mechanotransduction via interstitial fluid flow, both of which could contribute to bone fragility during postmenopausal osteoporosis.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
19 pages
Subject (authority = local)
Topic
Osteoporosis
Subject (authority = local)
Topic
Cortical porosity
Subject (authority = local)
Topic
Vascular porosity
Subject (authority = local)
Topic
Osteocyte lacunar porosity
Subject (authority = local)
Topic
Bone mechanotransduction
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2018
AssociatedObject
Name
Bone
Type
Journal
Relationship
Has part
Detail
1-10
Identifier (type = volume and issue)
110
Reference (type = url)
http://dx.doi.org/10.1016/j.bone.2018.01.019
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedEntity
Role
Originator
Name
Susannah P. Fritton
AssociatedObject
Type
Grant number
Name
R01- AR052866
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Science Foundation
AssociatedEntity
Role
Originator
Name
Luis Cardoso
AssociatedObject
Type
Grant number
Name
CBET-0723027
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Science Foundation
AssociatedEntity
Role
Originator
Name
Susannah P. Fritton; Luis Cardoso
AssociatedObject
Type
Grant number
Name
BMMB- 1400247
RelatedItem (type = host)
TitleInfo
Title
Fritton, J. Christopher
Identifier (type = local)
rucore30160500001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3RV0S3D
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RightsDeclaration (AUTHORITY = FS); (TYPE = [FS] statement #1); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsEvent
Type
Embargo
DateTime (encoding = w3cdtf); (point = end); (qualifier = exact); (keyDate = no)
2019-07-27
DateTime (encoding = w3cdtf); (point = start); (qualifier = exact); (keyDate = no)
2018-07-27
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after: 2019-07-27
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Technical

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ContentModel
Document
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1.6
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2018-01-04T19:56:45
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2018-07-27T15:25:17
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iPhone OS 11.2.1 Quartz PDFContext
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