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Characterization of a pre-vascularized biomimetic tissue engineered scaffold for bone
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Cipriano, James. Characterization of a pre-vascularized biomimetic tissue engineered scaffold for bone. Retrieved from https://doi.org/doi:10.7282/T35H7KQX

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TitleCharacterization of a pre-vascularized biomimetic tissue engineered scaffold for bone
NameCipriano, James (author); Freeman, Joseph W. (chair); Olabisi, Ronke (internal member); Dunn, Michael (internal member); Rutgers University; School of Graduate Studies
Date Created2018
Other Date2018-05 (degree)
SubjectBiomedical Engineering, Bone regeneration
Extent1 online resource (vii, 42 p. : ill.)
DescriptionSignificant bone loss due to disease or severe injury can result in the need for a bone graft, with over 500,000 procedures occurring each year in the United States. However, the current standards for grafting, autografts and allografts, can result in increased patient morbidity or a high rate of failure respectively. An ideal alternative would be a biodegradable tissue engineered graft that fulfils the function of bone while promoting the growth of new bone tissue. We developed a pre-vascularized tissue engineered scaffold of electrospun biodegradable polymers PLLA and PDLA reinforced with hydroxyapatite, a mineral similar to that found in bone. A composite design was utilized to mimic the structure and function of human trabecular and cortical bone. These scaffolds were characterized mechanically and in vitro to determine osteoinductive and angioinductive properties. It was observed that further reinforcement is necessary for the scaffolds to mechanically match bone, but the scaffolds are successful at inducing the differentiation of mesenchymal stem cells into mature bone cells. Pre-vascularization was seen to have a positive effect on angiogenesis and cellular viability, critical factors for the integration of a graft.
NoteM.S.
NoteIncludes bibliographical references
Noteby James Cipriano
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/T35H7KQX
Languageeng
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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