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Characterization of a pre-vascularized biomimetic tissue engineered scaffold for bone
Descriptive
TitleInfo
Title
Characterization of a pre-vascularized biomimetic tissue engineered scaffold for bone
Name
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NamePart
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Cipriano
NamePart
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James
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James Cipriano
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(authority = RULIB)
author
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Freeman
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Joseph W.
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Joseph W. Freeman
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Advisory Committee
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chair
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Olabisi
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Ronke
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Ronke Olabisi
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Advisory Committee
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internal member
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Dunn
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Michael
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Michael Dunn
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Advisory Committee
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internal member
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Rutgers University
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degree grantor
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School of Graduate Studies
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Text
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theses
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2018
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2018-05
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2018
Place
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xx
Language
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eng
Abstract
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Significant bone loss due to disease or severe injury can result in the need for a bone graft, with over 500,000 procedures occurring each year in the United States. However, the current standards for grafting, autografts and allografts, can result in increased patient morbidity or a high rate of failure respectively. An ideal alternative would be a biodegradable tissue engineered graft that fulfils the function of bone while promoting the growth of new bone tissue. We developed a pre-vascularized tissue engineered scaffold of electrospun biodegradable polymers PLLA and PDLA reinforced with hydroxyapatite, a mineral similar to that found in bone. A composite design was utilized to mimic the structure and function of human trabecular and cortical bone. These scaffolds were characterized mechanically and in vitro to determine osteoinductive and angioinductive properties. It was observed that further reinforcement is necessary for the scaffolds to mechanically match bone, but the scaffolds are successful at inducing the differentiation of mesenchymal stem cells into mature bone cells. Pre-vascularization was seen to have a positive effect on angiogenesis and cellular viability, critical factors for the integration of a graft.
Subject
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Topic
Biomedical Engineering
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Title
Rutgers University Electronic Theses and Dissertations
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ETD
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ETD_8855
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electronic resource
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application/pdf
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text/xml
Extent
1 online resource (vii, 42 p. : ill.)
Note
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M.S.
Note
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Includes bibliographical references
Subject
(authority = ETD-LCSH)
Topic
Bone regeneration
Note
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by James Cipriano
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Title
School of Graduate Studies Electronic Theses and Dissertations
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rucore10001600001
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NjNbRU
Identifier
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doi:10.7282/T35H7KQX
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Cipriano
GivenName
James
Role
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Permission or license
DateTime
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2018-04-11 19:57:41
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Name
James Cipriano
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Affiliation
Rutgers University. School of Graduate Studies
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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DateTime
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2018-05-31
DateTime
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2020-05-30
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after May 30th, 2020.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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