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Cellular and molecular studies of the human pathogen Chlamydia trachomatis
Descriptive
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Title
Cellular and molecular studies of the human pathogen Chlamydia trachomatis
Name
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Desai
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Malhar
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1993-
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Malhar Desai
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author
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Fondell
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Joseph
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Joseph Fondell
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Advisory Committee
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chair
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Fan
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Huizhou
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Huizhou Fan
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Advisory Committee
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internal member
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(type = family)
Millonig
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James
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James Millonig
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Advisory Committee
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internal member
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(type = family)
Walworth
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Nancy
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Nancy Walworth
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Advisory Committee
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internal member
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Rutgers University
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degree grantor
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School of Graduate Studies
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Text
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theses
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2018
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2018-05
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2018
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xx
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eng
Abstract
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Chlamydia trachomatis is a gram-negative bacterium and human pathogen responsible for the most prevalent sexually transmitted infection in the world. Epidemiologic studies indicate that the number of new C. trachomatis infections reported in the US likely approaches as much as 0.5 per a population of 100 every year. This, when paired with the fact that all current forms of treatment for C. trachomatis infections have unintended side effects including harm to gut and vaginal microbiota, has compelled many biologists to look to further research on C. trachomatis in hopes of developing new antichlamydial agents. In this thesis, I review several projects involving C. trachomatis that provide a framework for understanding both the growth and the developmental cycle of C. trachomatis. Through a mixture of in-depth proteomics, transcriptomics, and in vivo assays, I present five overall conclusions: (i) Lactobacilli-derived lactic acid, at concentrations that are physiological in the cervicovaginal lumen, can disrupt the outer membrane complex of and inactivate C. trachomatis; (ii) immunoprecipitation of chlamydial elementary bodies (EBs) using an antibody against a cell-surface protein of C. trachomatis is not an efficient method for purifying the bacterium; (iii) the growth of bacterial species that share significant sequence identity may not always be similar in media containing the same sera; (iv) the Chlamydia-specific transcription factor, GrgA, can stimulate transcription from promoters recognized by two different σ factors of C. trachomatis and has differential affinity for these two σ factors; (v) GrgA may associate with multiple subunits of the chlamydial RNA polymerase and, considering its role in transcription regulation and its specificity, may prove to be an excellent target for novel therapeutic agents against C. trachomatis.
Subject
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Topic
Physiology and Integrative Biology
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Rutgers University Electronic Theses and Dissertations
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ETD_8789
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electronic resource
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application/pdf
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text/xml
Extent
1 online resource (x, 101 p. : ill.)
Note
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M.S.
Note
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Includes bibliographical references
Subject
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Topic
Chlamydia trachomatis
Note
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by Malhar Desai
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TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
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rucore10001600001
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NjNbRU
Identifier
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doi:10.7282/T389199T
Genre
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ETD graduate
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Rights
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The author owns the copyright to this work.
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Name
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Desai
GivenName
Malhar
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Permission or license
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2018-04-09 15:22:31
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Name
Malhar Desai
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Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
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Type
License
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Embargo
DateTime
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2018-10-05
DateTime
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2020-05-31
Detail
Access to this PDF has been restricted at the author’s request. It will be publicly available after May 31, 2020.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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