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A collagen-hyaluronan infused 3d-printed polymeric scaffold for partial meniscus regeneration
Descriptive
TitleInfo
Title
A collagen-hyaluronan infused 3d-printed polymeric scaffold for partial meniscus regeneration
Name
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Ghodbane
NamePart
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Salim Amin
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Salim Amin Ghodbane
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author
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(type = personal)
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Dunn
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(type = given)
Michael G
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Michael G Dunn
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Advisory Committee
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chair
Name
(type = personal)
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(type = family)
Gatt
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(type = given)
Charles J
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Charles J Gatt
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Advisory Committee
Role
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co-chair
Name
(type = personal)
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(type = family)
Freeman
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(type = given)
Joseph W
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Joseph W Freeman
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Advisory Committee
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(authority = RULIB)
internal member
Name
(type = personal)
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(type = family)
Guvendiren
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(type = given)
Murat
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Murat Guvendiren
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Advisory Committee
Role
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outside member
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NamePart
Rutgers University
Role
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degree grantor
Name
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NamePart
School of Graduate Studies
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school
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Text
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theses
OriginInfo
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2018
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2018-05
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2018
Place
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xx
Language
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eng
Abstract
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The menisci are semilunar fibrocartilaginous disks, which serve several purposes within the tibiofemoral joint including shock absorption, force transmission, load distribution, joint stability, and lubrication. Partial meniscectomy is the gold standard for treatment of meniscal lesions and represents the most common orthopaedic surgical procedure with cost upwards of $4 billion per annum. This provides short term symptomatic relief but is known to increase the risk of osteoarthritis as a result of increased stresses on the articular surfaces with a well-documented link between meniscectomy volume and osteoarthritis. This has led to great interest in the regeneration of meniscal tissue. An ideal meniscus scaffold would be of an appropriate geometry to fit into the replacement site, facilitate cell attachment, infiltration, and distribution, and possess appropriate mechanical properties to stimulate the regeneration of meniscal tissue and protect the surrounding bone surfaces. 3D printing is a method of manufacturing in which materials are deposited onto one another in layers to produce three-dimensional structures. This method allows for the fabrication of complex and interconnected architectures needed to mimic the geometry of the native meniscus. The objective of this study was to develop an acellular, biomechanically functional scaffold for partial meniscus regeneration. The central hypothesis was a collagen-infused 3D-printed polymeric scaffold could be fabricated and implanted to 1) mimic the mechanical properties of the native meniscus, 2) be successfully fixed to the remaining native meniscal rim, 3) increase the contact area and reduce peak stresses relative to partial meniscectomy, 4) encourage cell infiltration, extracellular matrix production, and organized tissue deposition, 5) integrate robustly to the surrounding native meniscal tissue, and 6) protect the articular surfaces to prevent or delay degenerative changes.
Subject
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Topic
Biomedical Engineering
Subject
(authority = ETD-LCSH)
Topic
Meniscus (Anatomy)
RelatedItem
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Rutgers University Electronic Theses and Dissertations
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ETD_8752
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electronic resource
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application/pdf
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text/xml
Extent
1 online resource (xv, 178 p. : ill.)
Note
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Ph.D.
Note
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Includes bibliographical references
Note
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by Salim Amin Ghodbane
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Title
School of Graduate Studies Electronic Theses and Dissertations
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rucore10001600001
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NjNbRU
Identifier
(type = doi)
doi:10.7282/T3736VCV
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Ghodbane
GivenName
Salim
MiddleName
Amin
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(point = start)
2018-04-04 13:56:51
AssociatedEntity
Name
Salim Ghodbane
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Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
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(point = start)
2018-05-31
DateTime
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2020-05-30
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after May 30th, 2020.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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windows xp
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2018-04-04T13:54:26
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2018-04-04T13:54:26
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