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Localization of virus neutralizing I/LnJ H2-Oβ allele using confocal microscopy
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Katz, Jacqueline. Localization of virus neutralizing I/LnJ H2-Oβ allele using confocal microscopy. Retrieved from https://doi.org/doi:10.7282/T3251NN6

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TitleLocalization of virus neutralizing I/LnJ H2-Oβ allele using confocal microscopy
NameKatz, Jacqueline (author); Denzin, Lisa (chair); Covey, Lori (internal member); Bunting, Sam (internal member); Comoletti, Davide (outside member); Rutgers University; School of Graduate Studies
Date Created2018
Other Date2018-05 (degree)
SubjectCell and Developmental Biology
Extent1 online resource (vi, 37 p. : ill.)
DescriptionClass II MHC peptide presentation is a key process in the adaptive immune response and maintenance of self-tolerance. The loading of peptides on to the class II MHC molecule is facilitated by the non-classical MHC molecule H2-M. The actions of H2-M are inhibited when complexed with another non-classical MHC molecule, H2-O. A functionally null H2-O molecule has been identified in the I/LnJ strain of mice; this strain has the ability to clear persistent retroviruses that other strains (B6 and BALB/cJ) cannot. This study aims to localize the I/LnJ H2-O peptide in dendritic cells using confocal microscopy in order to determine if mis-localization of free I/LnJ H2-O contributes to the ability of I/LnJ mice to produce retrovirus neutralizing antibodies. Preliminary data suggests that free I/LnJ H2-O is localized to compartments other than the endosome and endoplasmic reticulum, which has been previously reported. Data suggests that free I/LnJ H2-O may localize to mitochondria, which introduces the potential for a novel H2-O function in these mice.
NoteM.S.
NoteIncludes bibliographical references
Noteby Jacqueline Katz
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/T3251NN6
Languageeng
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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