Nessel, Kimberly. The impact of psychosis on treatment response to cognitive behavioral therapy for depression in Parkinson's disease. Retrieved from https://doi.org/doi:10.7282/T3QZ2FGP
DescriptionDepression and psychosis are common psychiatric features of Parkinson’s disease that have a severe impact on quality of life, disease progression, and caregiver burden. There are currently several clinical trials investigating the efficacy of cognitive behavioral therapy (CBT) in treating depression in individuals diagnosed with Parkinson’s disease (PD). Psychosis is frequently an exclusionary criterion, as it may affect treatment response. The present study aimed to examine the impact of psychosis on treatment response to CBT for depression. Three individuals diagnosed with PD experiencing symptoms of psychosis as well as depression received ten weekly sessions of telehealth cognitive behavioral therapy. Each participant completed evaluations at baseline, the midpoint of the treatment, the end of treatment, and at one month follow-up. A case series format was utilized to further understand differences in treatment response between the three participants and to inform treatment recommendations for this population. Change scores and observed treatment effects were compared to those in published studies providing CBT to individuals experiencing depression without co-occurring symptoms of psychosis. In this study, two out of three participants showed clinically significant improvement in symptoms of depression. However, clinical improvement was minimal and only occurred in relation to symptoms of depression, without generalizing to other areas such as anxiety or negative thinking. It appears that co-occurring symptoms of psychosis may affect treatment response to a CBT intervention for depression in PD. With appropriate tailoring and modification, telehealth CBT could be an effective intervention for depression individuals with Parkinson’s disease experiencing symptoms of psychosis. Clinical recommendations and directions for future research are discussed. Results of this study should be considered carefully as the sample size was small.