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Reactive astrogliosis on electrospun nanoscale/microscale fiber scaffolds

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TitleInfo
Title
Reactive astrogliosis on electrospun nanoscale/microscale fiber scaffolds
Name (type = personal)
NamePart (type = family)
Chen
NamePart (type = given)
Han
NamePart (type = date)
1994-
DisplayForm
Han Chen
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
SHREIBER
NamePart (type = given)
DAVID IRA
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DAVID IRA SHREIBER
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Advisory Committee
Role
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chair
Name (type = personal)
NamePart (type = family)
Freeman
NamePart (type = given)
Joseph
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Joseph Freeman
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Cai
NamePart (type = given)
Li
DisplayForm
Li Cai
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
School of Graduate Studies
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateOther (qualifier = exact); (type = degree)
2018-10
CopyrightDate (encoding = w3cdtf); (keyDate = yes)
2018
Place
PlaceTerm (type = code)
xx
DateCreated (encoding = w3cdtf)
2018
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Astrocytes are glial cells that tiles the mammalian central nervous system. It serves a substantial function in the CNS and the progress of reactive astrogliosis is related to multiple CNS traumatic injuries and diseases. Recent years, the interest in understanding the trigger and the mechanism of reactive astrogliosis has increased and scientists have started to study reactive astrogliosis in vitro on scaffolds like electrospun polymer nanofibers. If it could be understood how various properties of the scaffold can affect reactive astrogliosis, we can then build scaffolds that are able guide/control the process of reactive astrogliosis and implanting such scaffolds in diseased brain tissue would become new treatment methods. In this project/thesis, effects of the orientation of electrospun nanofibers and the nanofibers of different materials on reactive astrogliosis have been studied. Results found that the orientation of the fiber scaffold can affect the extent of reactive astrogliosis and fiber diameter is a dominant factor than the chemical properties of the polymer. However, further study analyzing the effects other chemical and physical properties of the polymer scaffold on reactive astrogliosis needs to be done to fully understand the role of polymer nanoscale/microscale fiber scaffold in reactive astrogliosis.
Subject (authority = RUETD)
Topic
Biomedical Engineering
Subject (authority = LCSH)
Topic
Astrocytes
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
RelatedItem (type = host)
TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier (type = local)
rucore10001600001
Identifier
ETD_9291
Identifier (type = doi)
doi:10.7282/T3B56PBZ
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (viii, 49 pages : illustrations)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Han Chen
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

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The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Chen
GivenName
Han
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2018-10-01 16:24:17
AssociatedEntity
Name
Han Chen
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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ETD
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2018-10-03T13:46:39
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2018-10-03T13:46:39
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