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Inducing mechanical stresses in electroactive hydrogels to influence the fate of mesenchymal stem cells
Descriptive
TitleInfo
Title
Inducing mechanical stresses in electroactive hydrogels to influence the fate of mesenchymal stem cells
Name
(type = personal)
NamePart
(type = family)
Gupta
NamePart
(type = given)
Kriti
NamePart
(type = date)
1994-
DisplayForm
Kriti Gupta
Role
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(authority = RULIB)
author
Name
(type = personal)
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Olabisi
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Ronke
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Ronke Olabisi
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Advisory Committee
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chair
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Berthiaume
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Francois
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Francois Berthiaume
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Advisory Committee
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internal member
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Freeman
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(type = given)
Joseph
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Joseph Freeman
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Advisory Committee
Role
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internal member
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Rutgers University
Role
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degree grantor
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School of Graduate Studies
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Text
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theses
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2018
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2018-10
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2018
Place
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xx
Language
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eng
Abstract
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Mesenchymal stem cells (MSCs) can differentiate into bone, cartilage, muscle, tendon, and other mesenchyme-derived tissue with the right treatment of growth factors or the right mechanical stimuli. Therefore, these cells are widely used in tissue engineering. Though the MSC response to biochemical signals is well understood, their response to biophysical signals is still being described. Exploring the behavior of MSCs in response to a variety of biochemical, biophysical, or bioelectrical signals can lead to better scaffolds for tissue engineering. Scaffolds do not entirely mimic the native environment that cells experience, particularly for excitable tissues. For instance, in their native environment smooth muscle cells experience contraction and relaxation. While electroactive materials can deform, at present, few such materials are suitable as cell scaffolds. Herein, this thesis describes the development of poly(ethyelene glycol) diacrylate – poly(acrylic acid) (PEGDA-PAA) as an electroactive scaffold for MSCs. PEGDA-PAA hydrogels experience a change in volume with the application of an electric field, producing bending, wave-like movements similar to that of smooth muscle. Electroactive hydrogels were capable of deformation and seeded cells proliferated on the surface. Ongoing work is investigating a stimulation profile for the hydrogels that will be nonlethal for cells.
Subject
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Topic
Biomedical Engineering
Subject
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Topic
Mesenchymal stem cells
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Rutgers University Electronic Theses and Dissertations
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ETD_9276
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electronic resource
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text/xml
Extent
1 online resource (40 pages) : illustrations
Note
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M.S.
Note
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Includes bibliographical references
Note
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by Kriti Gupta
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School of Graduate Studies Electronic Theses and Dissertations
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rucore10001600001
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NjNbRU
Identifier
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doi:10.7282/t3-w63m-7j40
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
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The author owns the copyright to this work.
RightsHolder
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Name
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Gupta
GivenName
Kriti
Role
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Type
Permission or license
DateTime
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2018-09-28 09:11:34
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Name
Kriti Gupta
Role
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Affiliation
Rutgers University. School of Graduate Studies
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Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Embargo
DateTime
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2018-10-31
DateTime
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2019-05-02
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after May 2nd, 2019.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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