Home
Resource
Non-traditional application of drug and excipient
PDF
PDF format is widely accepted and good for printing.
Plug-in required
PDF-1(1.59 MB)
Citation & Export
View Usage Statistics
Staff View

Citation & Export
Hide

Simple citation

Khatri, Pinak Bharat. Non-traditional application of drug and excipient. Retrieved from https://doi.org/doi:10.7282/t3-aace-3t29

Export

Click here for information about Citation Management Tools at Rutgers.

Statistics
Hide

Description

TitleNon-traditional application of drug and excipient
NameKhatri, Pinak Bharat (author); Minko, Tamara (chair); Hatefi, Arash (internal member); Your, Guofeng (internal member); Desai, Dipen (outside member); Rutgers University; School of Graduate Studies
Date Created2018
Other Date2018-10 (degree)
SubjectPharmaceutical Science, Plasticizers, Active pharmaceutical ingredients
Extent1 online resource (141 pages) : illustrations
DescriptionDuring formulation development, there are cases when, serendipitously, drug or excipients play a different role than intended one or a dual role. One of the examples of a non-traditional role is of a drug acting as a plasticizer. Plasticization tendency of APIs on polymers can be advantageous for hot melt extrusion, and film coating application. Due to the inherent plasticizing property of API, it can be mixed uniformly with other polymers using a V-blender or high shear mixer without the use of additional organic solvents during the formulation process. Divalproex sodium (DVS) is shown to possess plasticization tendency on Ethylcellulose(EC) using thermal, mechanical and rheological characterization of films of DVS and EC. Also, further characterization of the films using polarized microscopy, TGA, FTIR, Raman spectroscopy revealed the physical nature of the drug and polymer along with their interactions. The plasticization tendency was attributed to the presence of valproic acid, which is a component that is bound by coordinate bond with sodium valproate to form DVS. This study shows the non-traditional role of API as a plasticizer for a polymer (EC).

Some polymers can play a non-traditional role or dual role in formulation development; for example-a surfactant(poloxamer) can be used as plasticizer in hot melt extrusion, while Sodium Lauryl Sulfate, a wetting agent, can act as lubricant in a tablet formulation. Compression property of a sustained release polymer can aid the formulation scientist since it can be used alone or with less amount of compression aid to formulate a direct compression immediate release tablet or sustained release tablet dosage form. Affinisol® HPMC HME polymers were developed by Dow Chemicals to cater the need of Formulation Scientist for a low Tg HPMC for HME applications since the traditionally available grades have HPMC have much higher Tg and require the addition of plasticizer. Due to the low Tg of Affinisol® HPMC HME polymers, it is proposed that it may possess better compactability at low compression pressure. The study was undertaken to evaluate the compaction property of these polymers. Furthermore, powder properties were also examined for its proposed use as a dry binder or a direct compression sustained release polymer. Based on the compaction and powder properties of these polymers, these polymers can be used for the potential application as a dry binder or a direct compression sustained release polymer in tablet formulations.
NotePh.D.
NoteIncludes bibliographical references
Noteby Pinak Bharat Khatri
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/t3-aace-3t29
Languageeng
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
Version 8.5.5
Rutgers University Libraries - Copyright ©2024