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Targeting lung cancer by identifying genes associated with resistance and developing lipid based nanodispersions for the inhalation delivery of therapeutic payloads

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TitleInfo
Title
Targeting lung cancer by identifying genes associated with resistance and developing lipid based nanodispersions for the inhalation delivery of therapeutic payloads
Name (type = personal)
NamePart (type = family)
Kuzmov
NamePart (type = given)
Andriy
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Andriy Kuzmov
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author
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Minko
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Tamara
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Tamara Minko
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Advisory Committee
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chair
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You
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Guofeng
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Guofeng You
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Advisory Committee
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internal member
Name (type = personal)
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Colaizzi
NamePart (type = given)
John
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John Colaizzi
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Advisory Committee
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internal member
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Garbuzenko
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Olga
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Olga Garbuzenko
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Advisory Committee
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outside member
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Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
School of Graduate Studies
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2018
DateOther (type = degree); (qualifier = exact)
2018-10
CopyrightDate (encoding = w3cdtf)
2018
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
The efficacy of cancer chemotherapy is limited by the development of resistance and intolerable side effects to conventional chemotherapeutic agents. To help overcome these barriers and improve the treatment of lung cancer, we propose the use of local inhalation delivery of chemotherapeutic drugs in combination of siRNA targeting pump and non-pump cellular resistance mechanism. To deliver the poorly soluble small molecule drug paclitaxel in combination with siRNA, we propose the use of a cationic lipid nanodispersion that can deliver the both therapeutic entities at the same time. To increase the targeting of the drug to cancer cells, LHRH peptide is attached to the delivery system. To reduce the particle size, improve the stability of the formulation, and improve its biocompatibility, we evaluate the effect of formulation buffer, solid lipids, and surfactant blends on the characteristics of the lipid dispersions. We report the formulation of gefitinib in the optimized lipid nanodispersions. To investigate the role of the PI3K/AKT pathway in the pathogenesis of cancer and development of resistance, we describe the evaluation of the gene expression of three cell lines with varying sensitivities to the EGFR inhibitor gefitinib.
Subject (authority = RUETD)
Topic
Pharmaceutical Science
Subject (authority = ETD-LCSH)
Topic
Chemotherapy
RelatedItem (type = host)
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Title
Rutgers University Electronic Theses and Dissertations
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ETD_9310
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electronic resource
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application/pdf
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text/xml
Extent
1 online resource (127 pages) : illustrations
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Andriy Kuzmov
RelatedItem (type = host)
TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier (type = local)
rucore10001600001
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NjNbRU
Identifier (type = doi)
doi:10.7282/t3-g68c-5n68
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Rights

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The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Kuzmov
GivenName
Andriy
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2018-10-01 23:26:22
AssociatedEntity
Name
Andriy Kuzmov
Role
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Affiliation
Rutgers University. School of Graduate Studies
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Type
Embargo
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2018-10-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2019-10-31
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 31st, 2019.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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2018-10-01T23:17:43
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2018-10-01T23:17:43
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