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Role of ATF4 in dietary sulfur amino acid restriction
Descriptive
TitleInfo
Title
Role of ATF4 in dietary sulfur amino acid restriction
Name
(type = personal)
NamePart
(type = family)
Margolies
NamePart
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Nicholas
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Nicholas Margolies
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author
Name
(type = personal)
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(type = family)
Anthony
NamePart
(type = given)
Tracy G
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Tracy G Anthony
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Advisory Committee
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chair
Name
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Bello
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Nicholas T
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Nicholas T Bello
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Advisory Committee
Role
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internal member
Name
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(type = family)
Belden
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(type = given)
William
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William Belden
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Advisory Committee
Role
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internal member
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Rutgers University
Role
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degree grantor
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School of Graduate Studies
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school
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Text
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theses
OriginInfo
DateCreated
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2018
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2018-10
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2018
Place
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xx
Language
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(type = code)
eng
Abstract
(type = abstract)
Dietary sulfur amino acid restriction (SAAR) increases food intake and energy expenditure and improves body composition. Dietary SAAR activates the integrated stress response (ISR), which orchestrates transcriptional changes through activating transcription factor 4 (ATF4). Fibroblast growth factor 21 (FGF21) is a hepatokine and ATF4 target which affects food and fluid intake, energy expenditure, and body composition. To determine whether ATF4 is needed to increase food and fluid intake and energy expenditure, improve body composition, and alter hepatic gene expression during SAAR, male and female wild type (WT) and Atf4-/- (KO) mice were maintained on a high fat (60% fat by Kcal) control (0.86% Met, 0% Cys) or high fat SAAR (0.12% Met, 0% Cys) diet for 5 weeks. SAAR increased hepatic Fgf21 and water intake independently of ATF4 in males and females. In males, SAAR increased food intake and energy expenditure independently of ATF4, while females showed no response. SAAR improved body composition in WT males but not females and did not prevent increased adiposity in male KO mice. ATF4 is required for protection from adiposity but not for increased food and water intake, energy expenditure, or hepatic Fgf21 expression during SAAR. FGF21 does not work exclusively through an ATF4-FGF21 axis and may be driving ATF4-independent responses to SAAR.
Subject
(authority = RUETD)
Topic
Endocrinology and Animal Biosciences
Subject
(authority = local)
Topic
Dietary sulfur amino acid restriction
Subject
(authority = local)
Topic
ATF4
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Rutgers University Electronic Theses and Dissertations
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ETD_9208
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electronic resource
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application/pdf
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text/xml
Extent
1 online resource (74 pages) : illustrations
Note
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M.S.
Note
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Includes bibliographical references
Note
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by Nicholas Margolies
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TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier
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rucore10001600001
Location
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NjNbRU
Identifier
(type = doi)
doi:10.7282/t3-n3td-6x66
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
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The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Margolies
GivenName
Nicholas
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(qualifier = exact);
(point = start)
2018-09-18 19:13:04
AssociatedEntity
Name
Nicholas Margolies
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Affiliation
Rutgers University. School of Graduate Studies
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License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
Type
Embargo
DateTime
(encoding = w3cdtf);
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(point = start)
2018-10-31
DateTime
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2020-10-30
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 30th, 2020.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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2018-10-15T14:20:20
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2018-10-15T14:20:20
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