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Electrospun nanofibers for the investigation of neural cell systems

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TitleInfo
Title
Electrospun nanofibers for the investigation of neural cell systems
Name (type = personal)
NamePart (type = family)
Sillitti
NamePart (type = given)
David
NamePart (type = date)
1989-
DisplayForm
David Sillitti
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Shreiber
NamePart (type = given)
David I
DisplayForm
David I Shreiber
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Freeman
NamePart (type = given)
Joseph
DisplayForm
Joseph Freeman
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Cai
NamePart (type = given)
Li
DisplayForm
Li Cai
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
School of Graduate Studies
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2019
DateOther (qualifier = exact); (type = degree)
2019-01
CopyrightDate (encoding = w3cdtf)
2019
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Polymer nanofibers and microfibers are an invaluable tool to biomedical research. Due to their versatility and customizability, fibers can be used to mimic various systems of the body such as the extracellular matrix and neuronal axons, and can be used to influence and study cell behavior. Electrospinning is an attractive method for generating these fibers in a high volume. Myoblasts were grown on random and aligned scaffolds of electrospun collagen nanofibers. Nanofiber anisotropy was shown to increase the fusion of myoblasts into multinucleated myotubes along the direction of the local fibers. Astrocytes cultured on electrospun Poly-L-Lactic acid nanofibers were found to have morphologies that were more similar to in-vivo astrocytes as compared to those cultured on glass. Larger nanofibers into the microfiber range were seen to induce a contact guidance effect, causing astrocytes to extend long processes along the fibers. Polymer microfibers with diameters similar to the diameter neuronal axons were used as a non-biological axon mimic which oligodendrocytes myelinate as if they were neurons. Fibers were functionalized by oxygen plasma activation and direct adsorption of Protein-A and CASPR2. Protein-A was used to bind and FC-Fusion version of CASPR2 to preserve the orientation of the protein along the fiber. Properly oriented protein increased myelination over control conditions.
Subject (authority = RUETD)
Topic
Biomedical Engineering
Subject (authority = ETD-LCSH)
Topic
Nanofibers
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_9365
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (68 pages) : illustrations
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by David Sillitti
RelatedItem (type = host)
TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier (type = local)
rucore10001600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/t3-d0ef-wv98
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Sillitti
GivenName
David
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2018-11-19 14:42:42
AssociatedEntity
Name
David Sillitti
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2019-03-19T09:49:36
CreatingApplication
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1.7
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