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Multidimensional hybrid nanomaterials for advanced theragnostic applications
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Yang, Letao. Multidimensional hybrid nanomaterials for advanced theragnostic applications. Retrieved from https://doi.org/doi:10.7282/t3-tmgr-v292

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TitleMultidimensional hybrid nanomaterials for advanced theragnostic applications
NameYang, Letao (author); Lee, Ki-Bum (chair); Li, Jing (internal member); Garfunkel, Eric (internal member); Cai, Li (outside member); Rutgers University; School of Graduate Studies
Date Created2019
Other Date2019-01 (degree)
SubjectChemistry and Chemical Biology, Nanomedicine
Extent1 online resource (321 pages) : illustrations
DescriptionNanomedicine is a multidisciplinary field that develops and translate biologically functionalized nanomaterials for the treatment or diagnosis of injuries and diseases. Taking advantage of the high surface-to-volume ratio and the unique physicochemical properties of nanomaterials, nanomedicine has shown great potential for many clinical theragnostic applications. In this dissertation, to further advance nanomaterials-based medical applications, multidimensional hybrid nanomaterials were developed by addressing the critical challenges of current nanotherapeutics. For cancer treatment, 0D-2D hybrid nanomaterials were synthesized and applied for the photothermal therapy-based cancer ablation by combining the surface property of 2D nanomaterials and the optical properties of plasmonic and carbon nanomaterial. To address the slow- or non-biodegradability of 2D carbon nanomaterials, 3D nanoscaffolds assembled from MnO2-based 2D nanomaterials were designed and synthesized for stem cell therapy. By further developing a 1D-2D hybrid nanostructure, highly sensitive biosensing platform was also fabricated using graphene and gold nanoarrays. Lastly, a method to high throughput print 0D, 1D and 2D nanostructures in a single platform was developed for providing quantitative design principles of nanomaterials-based medical applications. Collectively, by showcasing the design and synthesis of multidimensional nanomaterials for theragnostic applications, this dissertation is aimed to provide useful insights for the next generation precision and personalized medicine based on hybrid nanomaterials.
NotePh.D.
NoteIncludes bibliographical references
Noteby Letao Yang
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/t3-tmgr-v292
Languageeng
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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