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Direct numerical simulation of stress states in white matter via a triphasic continuum model of 3d axons tethered to glia
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DeSimone, Robert. Direct numerical simulation of stress states in white matter via a triphasic continuum model of 3d axons tethered to glia. Retrieved from https://doi.org/doi:10.7282/t3-2brh-7v29

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TitleDirect numerical simulation of stress states in white matter via a triphasic continuum model of 3d axons tethered to glia
NameDeSimone, Robert (author); Cuitino, Alberto (chair); Rutgers University; School of Graduate Studies
Date Created2019
Other Date2019-01 (degree)
SubjectMechanical and Aerospace Engineering, Axons, Stress concentration
Extent1 online resource (76 pages : illustrations)
DescriptionThree finite element sub-models were generated with the intent of studying stress propagation in axons under a uniaxial tensile load. The first sub-model used purely non-affine kinematics, where the axons acted independently from the ECM. The second and third sub-models used two different representations of oligodendrocytes to study how stress distributions in the axons are affected by the addition of glial cells. The two sub-models with oligodendrocytes had higher nominal stresses in the system, but lower peak stresses – indicating that the oligodendrocytes do support axons in the extracellular matrix and distribute stresses across the entire system. All three sub-models showed high stresses in regions with high tortuosity and bending stresses between all inflection points in the axon paths. Bending stresses indicate that the system can suffer from fatigue damage if subjected to repeated tensile and/or compressive loading.
NoteM.S.
NoteIncludes bibliographical references
Noteby Robert DeSimone
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/t3-2brh-7v29
Languageeng
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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